Yang Xin-Hua, Tian Kai, Wang Dong-Fang, Wang Yi, Cheung Eric F C, Xie Guang-Rong, Chan Raymond C K
Institute of Education, Rural Children and Adolescents Research Center for Health Promotion, Key Research Institute of Philosophies and Social Sciences in Hunan Province, Hunan Agricultural University, Changsha, China; Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Institute of Education, Rural Children and Adolescents Research Center for Health Promotion, Key Research Institute of Philosophies and Social Sciences in Hunan Province, Hunan Agricultural University, Changsha, China.
J Affect Disord. 2017 Aug 15;218:284-290. doi: 10.1016/j.jad.2017.04.053. Epub 2017 Apr 25.
Recent empirical findings have suggested that imbalanced neural networks may underlie the pathophysiology of major depressive disorder (MDD). However, the contribution of the superior temporal gyrus (STG) and the caudate nucleus to its pathophysiology remains unclear.
Functional magnetic resonance imaging (MRI) date were acquired from 40 patients with first-episode drug-naive MDD and 36 matched healthy controls during wakeful rest. We used whole-brain voxel-wise statistical maps to quantify within-group resting state functional connectivity (RSFC) and between-group differences of bilateral caudate and STG seeds.
Compared with healthy controls, first-episode MDD patients were found to have reduced connectivity between the ventral caudate and several brain regions including the superior frontal gyrus (SFG), the superior parietal lobule (SPL) and the middle temporal gyrus (MTG), as well as increased connectivity with the cuneus. We also found increased connectivity between the left STG and the precuneus, the angular gyrus and the cuneus. Moreover, we found that increased anhedonia severity was correlated with the magnitude of ventral caudate functional connectivity with the cuneus and the MTG in MDD patients.
Due to our small sample size, we did not correct the statistical threshold in the correlation analyses between clinical variables and connectivity abnormalities.
The present study suggests that anhedonia is mainly associated with altered ventral caudate-cortical connectivity and highlights the importance of the ventral caudate in the neurobiology of MDD.
最近的实证研究结果表明，神经网络失衡可能是重度抑郁症（MDD）病理生理学的基础。然而，颞上回（STG）和尾状核在其病理生理学中的作用仍不清楚。
在清醒静息状态下，从40例首发未用药的MDD患者和36例匹配的健康对照者中获取功能磁共振成像（MRI）数据。我们使用全脑体素级统计图谱来量化组内静息态功能连接（RSFC）以及双侧尾状核和STG种子的组间差异。
与健康对照相比，发现首发MDD患者腹侧尾状核与包括额上回（SFG）、顶上小叶（SPL）和颞中回（MTG）在内的几个脑区之间的连接减少，与楔叶的连接增加。我们还发现左侧STG与楔前叶、角回和楔叶之间的连接增加。此外，我们发现快感缺失严重程度的增加与MDD患者腹侧尾状核与楔叶和MTG的功能连接强度相关。
由于样本量小，我们在临床变量与连接异常的相关性分析中未校正统计阈值。
本研究表明，快感缺失主要与腹侧尾状核 - 皮质连接改变有关，并突出了腹侧尾状核在MDD神经生物学中的重要性。
