Department of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
School of Public Health and Primary Care, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.
Biosens Bioelectron. 2017 Oct 15;96:127-139. doi: 10.1016/j.bios.2017.04.032. Epub 2017 Apr 25.
Metal ion detection is critical in a variety of areas. The past decade has witnessed great progress in the development of metal ion sensors using functional nucleic acids (FNAs) and nanomaterials. The former has good recognition selectivity toward metal ions and the latter possesses unique properties for enhancing the performance of metal ion sensors. This review offers a summary of FNA- and nanomaterial-based metal ion detection methods. FNAs mainly include DNAzymes, G-quadruplexes, and mismatched base pairs and nanomaterials cover gold nanoparticles (GNPs), quantum dots (QDs), carbon nanotubes (CNTs), and graphene oxide (GO). The roles of FNAs and nanomaterials are introduced first. Then, various methods based on the combination of different FNAs and nanomaterials are discussed. Finally, the challenges and future directions of metal ion sensors are presented.
金属离子检测在许多领域都至关重要。过去十年，利用功能核酸（FNAs）和纳米材料开发金属离子传感器方面取得了重大进展。前者对金属离子具有良好的识别选择性，后者则具有提高金属离子传感器性能的独特性质。本文综述了基于 FNA 和纳米材料的金属离子检测方法。FNAs 主要包括 DNA 酶、G-四链体和错配碱基对，纳米材料包括金纳米颗粒（GNPs）、量子点（QDs）、碳纳米管（CNTs）和氧化石墨烯（GO）。本文首先介绍了 FNAs 和纳米材料的作用，然后讨论了基于不同 FNAs 和纳米材料组合的各种方法，最后提出了金属离子传感器面临的挑战和未来发展方向。
