Department of Applied Chemistry, School of Science, Anhui Agricultural University, Hefei 230036, China.
Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114, China.
Molecules. 2019 Nov 19;24(22):4189. doi: 10.3390/molecules24224189.
DNA-templated fluorescent nanoclusters (NCs) have attracted increasing research interest on account of their prominent features, such as DNA sequence-dependent fluorescence, easy functionalization, wide availability, water solubility, and excellent biocompatibility. Coupling DNA templates with complementary DNA, aptamers, G-quadruplex, and so on has generated a large number of sensors. Additionally, the preparation and applications of DNA-templated fluorescent NCs in these sensing have been widely studied. This review firstly focuses on the properties of DNA-templated fluorescent NCs, and the synthesis of DNA-templated fluorescent NCs with different metals is then discussed. In the third part, we mainly introduce the applications of DNA-templated fluorescent NCs for sensing metal ions. At last, we further discuss the future perspectives of DNA-templated fluorescent NCs in the synthesis and sensing metal ions in the environmental and biological fields.
基于 DNA 的荧光纳米团簇（NCs）由于其独特的性质，如 DNA 序列依赖性荧光、易于功能化、广泛可用性、水溶性和出色的生物相容性，引起了越来越多的研究兴趣。将 DNA 模板与互补 DNA、适体、G-四链体等结合，产生了大量的传感器。此外，DNA 模板荧光 NCs 的制备及其在这些传感中的应用也得到了广泛的研究。本综述首先重点介绍了基于 DNA 的荧光 NCs 的性质，然后讨论了不同金属的 DNA 模板荧光 NCs 的合成。在第三部分，我们主要介绍了 DNA 模板荧光 NCs 在金属离子传感中的应用。最后，我们进一步讨论了 DNA 模板荧光 NCs 在环境和生物领域合成和传感金属离子的未来前景。
