Weaver John M, Liu Ke Jian
Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Center of Biomedical Research Excellence, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Med Gas Res. 2017 Mar 30;7(1):56-67. doi: 10.4103/2045-9912.202911. eCollection 2017 Jan-Mar.
Molecular oxygen (O) is essential to brain function and mechanisms necessary to regulate variations in delivery or utilization of O are crucial to support normal brain homeostasis, physiology and energy metabolism. Any imbalance in cerebral tissue partial pressure of O (pO) levels may lead to pathophysiological complications including increased reactive O species generation leading to oxidative stress when tissue O level is too high or too low. Accordingly, the need for oximetry methods, which assess cerebral pO and in real time, is imperative to understand the role of O in various metabolic and disease states, including the effects of treatment and therapy options. In this review, we provide a brief overview of the common oximetry methodologies for measuring cerebral pO. We discuss the advantages and limitations of oximetry methodologies to measure cerebral pO followed by a more in-depth review of electron paramagnetic resonance oximetry spectroscopy and imaging using several examples of current electron paramagnetic resonance oximetry applications in the brain.
分子氧（O₂）对脑功能至关重要，调节氧输送或利用变化所必需的机制对于维持正常的脑稳态、生理功能和能量代谢至关重要。脑组织氧分压（pO₂）水平的任何失衡都可能导致病理生理并发症，包括当组织氧水平过高或过低时活性氧生成增加，从而导致氧化应激。因此，迫切需要能够实时评估脑pO₂的血氧测定方法，以了解O₂在各种代谢和疾病状态中的作用，包括治疗和治疗方案的效果。在这篇综述中，我们简要概述了用于测量脑pO₂的常见血氧测定方法。我们讨论了测量脑pO₂的血氧测定方法的优点和局限性，随后使用当前脑电子顺磁共振血氧测定应用的几个例子，对电子顺磁共振血氧测定光谱和成像进行更深入的综述。
