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放射疫苗接种假说。

Radiovaccination Hypothesis.

作者信息

Eapen Libni

机构信息

Radiation Medicine Program, The Ottawa Hospital Cancer Centre.

出版信息

Cureus. 2017 Apr 4;9(4):e1135. doi: 10.7759/cureus.1135.

DOI:10.7759/cureus.1135
PMID:28480153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5418027/
Abstract

The details of patients who have entered remission from metastatic melanoma following palliative radiotherapy are reported. We review the relevant immune physiology and radiotherapy particulars and propose the hypothesis that radiovaccination with high fractional dose to skin metastases can stimulate the development of a robust systemic anti-tumoral immune response capable of causing remission of metastatic disease.

摘要

报告了经姑息性放疗后转移性黑色素瘤进入缓解期的患者详情。我们回顾了相关的免疫生理学和放疗细节，并提出假说：对皮肤转移灶给予高分次剂量的放射疫苗接种可刺激强大的全身性抗肿瘤免疫反应的发展，从而使转移性疾病缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/71c98c3e5c5f/cureus-0009-00000001135-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/ce10a7ff29b0/cureus-0009-00000001135-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/4f30bbd03f11/cureus-0009-00000001135-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/e81d28c7b5e9/cureus-0009-00000001135-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/71c98c3e5c5f/cureus-0009-00000001135-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/ce10a7ff29b0/cureus-0009-00000001135-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/4f30bbd03f11/cureus-0009-00000001135-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/e81d28c7b5e9/cureus-0009-00000001135-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f3d/5418027/71c98c3e5c5f/cureus-0009-00000001135-i04.jpg

相似文献

1
Radiovaccination Hypothesis.放射疫苗接种假说。
Cureus. 2017 Apr 4;9(4):e1135. doi: 10.7759/cureus.1135.
2
Palliative radiotherapy for recurrent and metastatic malignant melanoma: prognostic factors for tumor response and long-term outcome: a 20-year experience.复发性和转移性恶性黑色素瘤的姑息性放疗：肿瘤反应和长期结局的预后因素：20年经验
Int J Radiat Oncol Biol Phys. 1999 Jun 1;44(3):607-18. doi: 10.1016/s0360-3016(99)00066-8.
3
Radiotherapy as palliative treatment for metastatic melanoma.放射治疗作为转移性黑色素瘤的姑息治疗手段。
Melanoma Res. 1999 Dec;9(6):611-3. doi: 10.1097/00008390-199912000-00012.
4
Palliative radiotherapy for metastatic malignant melanoma: brain metastases, bone metastases, and spinal cord compression.转移性恶性黑色素瘤的姑息性放疗：脑转移、骨转移和脊髓压迫
Int J Radiat Oncol Biol Phys. 1988 Oct;15(4):859-64. doi: 10.1016/0360-3016(88)90118-6.
5
Organ- and treatment-specific local response rates to systemic and local treatment modalities in stage IV melanoma.IV期黑色素瘤中针对全身和局部治疗方式的器官及治疗特异性局部缓解率。
Br J Dermatol. 2005 Nov;153(5):925-31. doi: 10.1111/j.1365-2133.2005.06796.x.
6
A phase II trial of stereotactic body radiotherapy with concurrent anti-PD1 treatment in metastatic melanoma: evaluation of clinical and immunologic response.一项转移性黑色素瘤立体定向体部放射治疗联合抗PD1治疗的II期试验：临床和免疫反应评估
J Transl Med. 2017 Jan 31;15(1):21. doi: 10.1186/s12967-017-1123-x.
7
Combined Immune Checkpoint Blockade and Stereotactic Ablative Radiotherapy Can Stimulate Response to Immunotherapy in Metastatic Melanoma: A Case Report.联合免疫检查点阻断与立体定向消融放疗可增强转移性黑色素瘤对免疫治疗的反应：一例报告
Cureus. 2019 Feb 8;11(2):e4038. doi: 10.7759/cureus.4038.
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Systemic melanoma metastatic to the retina and vitreous.转移性系统性黑色素瘤累及视网膜和玻璃体。
Ophthalmologica. 2004 Nov-Dec;218(6):424-33. doi: 10.1159/000080948.
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The use of systemic therapies for the treatment of brain metastases in metastatic melanoma: opportunities and unanswered questions.系统治疗在转移性黑色素瘤脑转移中的应用：机遇与未解问题。
Cancer Treat Rev. 2013 Dec;39(8):833-8. doi: 10.1016/j.ctrv.2013.06.004. Epub 2013 Jul 9.
10
Tumoral Melanosis Associated with Pembrolizumab-Treated Metastatic Melanoma.与帕博利珠单抗治疗的转移性黑色素瘤相关的肿瘤性黑素沉着症
Cureus. 2017 Feb 13;9(2):e1026. doi: 10.7759/cureus.1026.

引用本文的文献

1
Impressive Results after "Metabolism-Guided" Lattice Irradiation in Patients Submitted to Palliative Radiation Therapy: Preliminary Results of LATTICE_01 Multicenter Study.姑息性放射治疗患者接受“代谢引导”点阵放疗后的显著效果：LATTICE_01多中心研究的初步结果
Cancers (Basel). 2022 Aug 12;14(16):3909. doi: 10.3390/cancers14163909.

本文引用的文献

1
The abscopal effect associated with a systemic anti-melanoma immune response.与全身性抗黑色素瘤免疫反应相关的远隔效应。
Int J Radiat Oncol Biol Phys. 2013 Feb 1;85(2):293-5. doi: 10.1016/j.ijrobp.2012.03.017. Epub 2012 May 5.
2
Immunologic correlates of the abscopal effect in a patient with melanoma.黑色素瘤患者的远隔效应的免疫相关性。
N Engl J Med. 2012 Mar 8;366(10):925-31. doi: 10.1056/NEJMoa1112824.
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Taking dendritic cells into medicine.将树突状细胞应用于医学。
Nature. 2007 Sep 27;449(7161):419-26. doi: 10.1038/nature06175.
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Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.免疫系统通过Toll样受体4对癌症化疗和放疗的作用
Nat Med. 2007 Sep;13(9):1050-9. doi: 10.1038/nm1622. Epub 2007 Aug 19.
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Activation and route of administration both determine the ability of bone marrow-derived dendritic cells to accumulate in secondary lymphoid organs and prime CD8+ T cells against tumors.激活方式和给药途径均决定了骨髓来源的树突状细胞在次级淋巴器官中积聚以及启动CD8 + T细胞对抗肿瘤的能力。
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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy.辐射可调节肽库，增强I类主要组织相容性复合体（MHC）的表达，并诱导成功的抗肿瘤免疫疗法。
J Exp Med. 2006 May 15;203(5):1259-71. doi: 10.1084/jem.20052494. Epub 2006 Apr 24.
7
External beam radiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing.肿瘤的外照射放疗会改变肿瘤细胞的表型，使其易于被疫苗介导的T细胞杀伤。
Cancer Res. 2004 Jun 15;64(12):4328-37. doi: 10.1158/0008-5472.CAN-04-0073.
8
Dendritic cells: unique leukocyte populations which control the primary immune response.树突状细胞：控制初次免疫反应的独特白细胞群体。
Blood. 1997 Nov 1;90(9):3245-87.
9
Langerhans cells as macrophages in skin and lymphoid organs.朗格汉斯细胞作为皮肤和淋巴器官中的巨噬细胞。
J Invest Dermatol. 1980 Jul;75(1):32-43. doi: 10.1111/1523-1747.ep12521083.