Thorbecke G J, Silberberg-Sinakin I, Flotte T J
J Invest Dermatol. 1980 Jul;75(1):32-43. doi: 10.1111/1523-1747.ep12521083.
Properties of epidermal Langerhans cell were compared with those of a number of other dendritic cells in lymphoid organs and of mononuclear phagocytes. Among the dendritic "reticulum" cells included were indeterminate cells from the epidermis, interdigitating "reticulum" cells from T-dependent areas of lymphoid tissue and thymus, follicular dendritic cells of Nossal, and the dendritic cells described by Steinman and Cohn. Interdigitating cells with typical Birbeck granules, in the thymus and in the paracortices of lymph nodes, which are morphologically indistinguishable from Langerhans cells and indeterminate dendritic cells in the epidermis, appear to belong to the same system and possibly represent a subpopulation of "macrophages." On the basis of their similarity to these other dendritic cells, we believe Langerhans cells may function in antigen presentation, lymphokine production, provision of a microenvironment for T lymphocytes, and prostaglandin secretion.
将表皮朗格汉斯细胞的特性与淋巴器官中的许多其他树突状细胞以及单核吞噬细胞的特性进行了比较。所包括的树突状“网状”细胞有来自表皮的未定型细胞、来自淋巴组织和胸腺的T细胞依赖区的交错“网状”细胞、诺萨尔的滤泡树突状细胞以及斯坦曼和科恩描述的树突状细胞。在胸腺和淋巴结副皮质中具有典型伯贝克颗粒的交错细胞，在形态上与表皮中的朗格汉斯细胞和未定型树突状细胞无法区分，它们似乎属于同一系统，可能代表“巨噬细胞”的一个亚群。基于它们与这些其他树突状细胞的相似性，我们认为朗格汉斯细胞可能在抗原呈递、淋巴因子产生、为T淋巴细胞提供微环境以及前列腺素分泌方面发挥作用。
