Sayed Amany A, Sadek Shimaa A, Solimán Amel M, Marzouk Mohamed
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):231-241. doi: 10.21010/ajtcam.v14i1.25. eCollection 2017.
Osteoarthritis (OA) is a progressive disease characterized by joints pain and articular cartilage destruction. Most of the current treatment strategies for OA are effective for symptoms relief but are accompanied with adverse side effect. Thus, the present investigation aims to evaluate the potential influence of red algae, , in the dry powder form (AFP) or gel form (AFG) on some relevant factors of OA progression as well as assess its safety through and experiments.
, AFP was analyzed for its chemical constituents screening, amino acid, proteinase inhibitory activity, HRBC membrane stabilization activity, free radical scavenging activity, total antioxidant potency, nitric oxide radical scavenging power. , Organization for Economic Co-operation and Development (OECD) toxicity test was performed to test the safety of AFP on rats.
The present findings revealed that AFP and AFG can be considered as inflammatory-proteinase-oxidant inhibitor and considered to be safe according to the OECD guideline.
AFP and AFG may have the potency to become the therapeutic candidate for OA disease as it prevents the key causes of OA initiation.
骨关节炎（OA）是一种以关节疼痛和关节软骨破坏为特征的进行性疾病。目前大多数针对OA的治疗策略对缓解症状有效，但伴有不良副作用。因此，本研究旨在评估干粉形式（AFP）或凝胶形式（AFG）的红藻对OA进展的一些相关因素的潜在影响，并通过……和……实验评估其安全性。
对AFP进行化学成分筛选、氨基酸分析、蛋白酶抑制活性、人红细胞膜稳定活性、自由基清除活性、总抗氧化能力、一氧化氮自由基清除能力分析。对大鼠进行经济合作与发展组织（OECD）毒性试验以测试AFP的安全性。
目前的研究结果表明，AFP和AFG可被视为炎性蛋白酶氧化剂抑制剂，根据经合组织指南被认为是安全的。
AFP和AFG可能有潜力成为OA疾病的治疗候选药物，因为它能预防OA发病的关键原因。
