Apondi Ogalo Edith, Oduor Owuor Chrispine, Gye Boor Kipyego, Kipkoech Mutai Kennedy
Department of Child Health and Pediatrics, Moi Teaching and Referral Hospital, Eldoret. Kenya.
Department of Internal Medicine, Moi University, Eldoret, Kenya (
Afr J Infect Dis. 2016 May 1;10(2):89-95. doi: 10.21010/ajid.v10i2.3. eCollection 2016.
is a gram negative commonly associated with nosocomial infections. Multidrug resistant strains are increasingly being reported with corresponding increase in morbidity and mortality. The study outlines the epidemiology and antibiotic resistance pattern of over a 10 year period in Moi Teaching and Referral Hospital, Eldoret, Kenya.
This is a retrospective analysis of all the blood culture results for isolates in the hospital for the period 2002-2013.
accounted for 23% of the hospital isolates (231/1356) during the study period; of these, 82.6% were from the New Born Unit. Most of the isolates were multi drug resistant with highest resistance of over 80% to Penicillins, Cephalosporins, Macrolides, Tetracyclines, Sulphonamides, Lincosamides and Chloramphenicol. Aminoglycoside and Quinolone resistance was also high at 49.2% and 41.3% respectively. The lowest resistance rates were documented for Carbapenems (23.2%). For specific antibiotics, there was high resistance to commonly used antibiotics (over 80% for Ceftriaxone, Cefipime, Gentamycin and Ceftazidime). The antibiotics with least resistance were Amikacin and Meropenem (21% and 7 % respectively).
There was a high prevalence of multidrug resistant isolates in the hospital, the majority originated from the New Born Unit. Resistance to third generation Cephalosporins and Gentamycin was high while Meropenem and Amikacin had the least resistance.
是一种革兰氏阴性菌，通常与医院感染有关。多药耐药菌株的报道日益增多，发病率和死亡率也相应增加。本研究概述了肯尼亚埃尔多雷特市莫伊教学与转诊医院10年间的流行病学及抗生素耐药模式。
这是一项对2002年至2013年期间该医院所有分离株血培养结果的回顾性分析。
在研究期间，该菌占医院分离株的23%（231/1356）；其中，82.6%来自新生儿病房。大多数分离株具有多重耐药性，对青霉素、头孢菌素、大环内酯类、四环素类、磺胺类、林可酰胺类和氯霉素的耐药率最高，超过80%。氨基糖苷类和喹诺酮类的耐药率也较高，分别为49.2%和41.3%。碳青霉烯类的耐药率最低（23.2%）。对于特定抗生素，对常用抗生素的耐药性较高（头孢曲松、头孢吡肟、庆大霉素和头孢他啶的耐药率超过80%）。耐药性最低的抗生素是阿米卡星和美罗培南（分别为21%和7%）。
该医院多重耐药分离株的患病率较高，大多数起源于新生儿病房。对第三代头孢菌素和庆大霉素的耐药性较高，而美罗培南和阿米卡星的耐药性最低。
