Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.
Lab Chip. 2017 May 31;17(11):1856-1883. doi: 10.1039/c7lc00242d.
The microfluidic technique has brought unique opportunities toward the full control over the production processes for drug delivery carriers, owing to the miniaturisation of the fluidic environment. In comparison to the conventional batch methods, the microfluidic setup provides a range of advantages, including the improved controllability of material characteristics, as well as the precisely controlled release profiles of payloads. This review gives an overview of different fluidic principles used in the literature to produce either polymeric microparticles or nanoparticles, focusing on the materials that could have an impact on drug delivery. We also discuss the relations between the particle size and size distribution of the obtained carriers, and the design and configuration of the microfluidic setups. Overall, the use of microfluidic technologies brings exciting opportunities to expand the body of knowledge in the field of controlled drug delivery and great potential to clinical translation of drug delivery systems.
微流控技术通过将流体环境微型化，为药物输送载体的生产过程提供了全面控制的独特机会。与传统的批量方法相比，微流控装置具有一系列优势，包括改善材料特性的可控性，以及对有效载荷的精确控制释放。本综述概述了文献中用于制备聚合物微球或纳米颗粒的不同流体原理，重点介绍了可能对药物输送产生影响的材料。我们还讨论了所获得载体的粒径和粒径分布，以及微流控装置的设计和配置之间的关系。总的来说，微流控技术的使用为扩展控释药物输送领域的知识体系带来了令人兴奋的机会，并为药物输送系统的临床转化提供了巨大的潜力。
