Gong Zehua, Chen Linjie, Zhou Xiaolei, Zhang Chunwu, Matičić Dražen, Vnuk Dražen, You Zhifeng, Li Linjin, Li Huaqiong
Joint Research Centre on Medicine Xiangshan Hospital of Wenzhou Medical University Ningbo China.
Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences Wenzhou China.
Smart Med. 2025 Apr 13;4(2):e70006. doi: 10.1002/smmd.70006. eCollection 2025 Jun.
Osteoarthritis (OA) is a physical lubrication microenvironment-inadequate disease accompanied by a sustained chronic chemical inflammation microenvironment and the progression of articular cartilage destruction. Despite the promising OA treatment outcomes observed in the enhancement of lubrication inspired by ball bearings to reduce friction and support loads, the therapeutic effect of near-infrared (NIR) irradiation-based photothermal-responsive controlled release "smart hydrogel microspheres" on OA remains unclear. Here, we prepared MXene/NIPIAM-based photothermal-responsive injectable hydrogel microspheres encapsulating diclofenac sodium using a microfluidic system. Consequently, NIR irradiation-based photothermal-responsive controlled release "smart hydrogel microspheres" demonstrate beneficial therapeutic effects in the treatment of OA by modulating the physical lubrication and chemical chronic inflammation microenvironment, laying the foundation for the application of smart hydrogel microsphere delivery systems loaded with bioactive factors (including agents, cells, and factors) to regulate multiple pathological microenvironments in regenerative medicine.
骨关节炎（OA）是一种物理润滑微环境不足的疾病，伴有持续的慢性化学炎症微环境以及关节软骨破坏的进展。尽管在受滚珠轴承启发增强润滑以减少摩擦和支撑负荷方面观察到了有前景的OA治疗效果，但基于近红外（NIR）照射的光热响应控释“智能水凝胶微球”对OA的治疗效果仍不清楚。在此，我们使用微流控系统制备了包裹双氯芬酸钠的基于MXene/NIPIAM的光热响应可注射水凝胶微球。因此，基于NIR照射的光热响应控释“智能水凝胶微球”通过调节物理润滑和化学慢性炎症微环境在OA治疗中显示出有益的治疗效果，为负载生物活性因子（包括药物、细胞和因子）的智能水凝胶微球递送系统在再生医学中调节多种病理微环境的应用奠定了基础。
