韩国一名急性发热性疾病患者中贝氏柯克斯体的临床和遗传特征
Clinical and Genetic Features of Coxiella burnetii in a Patient with an Acute Febrile Illness in Korea.
作者信息
Lee Seung Hun, Heo Jung Yeon, Lee Hae Kyung, Lee Yeong Seon, Jeong Hye Won, Hwang Seon Do
机构信息
Division of Zoonoses, Center for Immunology & Pathology, Korea National Institute of Health, Korea Centers for Disease Control & Prevention, Cheongju, Korea.
Division of Infectious Diseases, Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
出版信息
J Korean Med Sci. 2017 Jun;32(6):1038-1041. doi: 10.3346/jkms.2017.32.6.1038.
Although Q fever is an important zoonotic infection with a worldwide distribution, no human isolates of Coxiella burnetii have been identified in Korea. For the first time, we identified the nucleotide sequence of C. burnetii from a 32-year-old man with an acute febrile illness in Korea. Diagnosis of acute Q fever was confirmed by seroconversion using indirect immunofluorescence antibody assays. Phylogenetic analysis demonstrated high sequence similarity (99.6%-100%) with C. burnetii 16S rRNA sequences identified from the reservoir. These results are the first genetic analysis of C. burnetii in a human case of Q fever in Korea.
尽管Q热是一种分布于全球的重要人畜共患感染病，但韩国尚未发现人型伯纳特立克次体分离株。我们首次从韩国一名患有急性发热性疾病的32岁男性身上鉴定出了伯纳特立克次体的核苷酸序列。通过间接免疫荧光抗体试验进行血清学转换，确诊为急性Q热。系统发育分析表明，与从储存宿主中鉴定出的伯纳特立克次体16S rRNA序列具有高度的序列相似性（99.6%-100%）。这些结果是韩国首例人类Q热病例中伯纳特立克次体的首次基因分析。
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