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病例报告：荷兰科克斯体血管感染和淋巴瘤。

Case report: Coxiella burnetii vascular infection and lymphoma in the Netherlands.

机构信息

Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

CNRS, IRD, INSERM, AP-HM, URMITE, IHU, Méditerranée Infection, Aix Marseille Université, 19-21 Boulevard Jean Moulin, 13385, Cedex 05,, Marseille, France.

出版信息

Infection. 2018 Feb;46(1):131-134. doi: 10.1007/s15010-017-1061-9. Epub 2017 Aug 24.

DOI:10.1007/s15010-017-1061-9
PMID:28840502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5790848/
Abstract

OBJECTIVES AND DESIGN

Non-Hodgkin lymphoma has been linked to infection with Coxiella burnetii, potentially through overproduction of IL-10 during infection with C. burnetii.

MATERIALS AND METHODS

Description of a case report.

RESULTS

We describe a patient with retroperitoneal non-Hodgkin lymphoma and vascular infection with C. burnetii. Immunofluorescence staining and fluorescence in situ hybridization targeting specific C. burnetii 16S rRNA were performed on the retroperitoneal lymphoma tissue sample obtained at diagnosis of NHL. Both were strongly positive for the presence of C. burnetii.

CONCLUSIONS

This case provokes questions regarding a potential association between C. burnetii and NHL, and underlines the importance of further exploration of this association.

摘要

目的和设计

非霍奇金淋巴瘤与感染贝纳柯克斯体有关，可能是通过感染贝纳柯克斯体时过度产生 IL-10。

材料和方法

病例报告描述。

结果

我们描述了一名患有腹膜后非霍奇金淋巴瘤和血管感染贝纳柯克斯体的患者。在 NHL 诊断时获得的腹膜后淋巴瘤组织样本上进行了免疫荧光染色和针对特定贝纳柯克斯体 16S rRNA 的荧光原位杂交。两者均对贝纳柯克斯体的存在呈强阳性。

结论

该病例引发了关于贝纳柯克斯体与 NHL 之间潜在关联的问题，并强调了进一步探索这种关联的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12d3/5790848/bab7e8a5d326/15010_2017_1061_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12d3/5790848/bab7e8a5d326/15010_2017_1061_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12d3/5790848/bab7e8a5d326/15010_2017_1061_Fig1_HTML.jpg

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