Theoharides Theoharis C, Stewart Julia M, Tsilioni Irene
1 Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA.
2 Sackler School of Graduate Biomedical Sciences and Tufts University School of Medicine, Boston, MA, USA.
Int J Immunopathol Pharmacol. 2017 Jun;30(2):146-151. doi: 10.1177/0394632017707610. Epub 2017 May 8.
As many as 40% of people have sensitive skin and at least half of them suffer from pruritus associated with allergies, atopic dermatitis (AD), chronic urticaria (CU), cutaneous mastocytosis (CM), and psoriasis. Unfortunately, the available topical formulations contain antihistamines that are often not as effective as those containing corticosteroids. Certain natural flavonoids have anti-inflammatory actions. We recently reported that the natural flavonoid tetramethoxyluteolin has potent antiallergic and anti-inflammatory actions in vitro and in vivo. This flavonoid was formulated in a skin lotion along with olive fruit extract and was first tested for tolerability in 25 patients with mastocytosis or mast cell activation syndrome and very sensitive skin who reported back through a questionnaire. The skin lotion was then used by eight patients, four with AD and four with psoriasis, who had not received any topical treatment for at least 2 months, twice daily for 2 weeks. The use of this tetramethoxyluteolin formulation resulted in significant improvement of the skin lesions and could be useful adjuvant treatment for allergic and inflammatory skin conditions.
多达40%的人有敏感性皮肤，其中至少一半患有与过敏、特应性皮炎（AD）、慢性荨麻疹（CU）、皮肤肥大细胞增多症（CM）和银屑病相关的瘙痒。不幸的是，现有的局部用制剂含有抗组胺药，其效果往往不如含皮质类固醇的制剂。某些天然黄酮类化合物具有抗炎作用。我们最近报道，天然黄酮类化合物四甲氧基木犀草素在体外和体内均具有强大的抗过敏和抗炎作用。这种黄酮类化合物与橄榄果提取物一起被制成护肤液，并首先在25名患有肥大细胞增多症或肥大细胞活化综合征且皮肤非常敏感的患者中进行了耐受性测试，这些患者通过问卷调查进行反馈。然后，八名患者使用了这种护肤液，其中四名患有特应性皮炎，四名患有银屑病，他们至少2个月未接受任何局部治疗，每天使用两次，持续2周。使用这种四甲氧基木犀草素制剂可使皮肤损伤得到显著改善，可能是过敏性和炎性皮肤病的有用辅助治疗方法。
