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Reply to Fattori et al.: Action of SP and IL-33 on mast cells.对法托里等人的回复：速激肽和白细胞介素-33对肥大细胞的作用。
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10036. doi: 10.1073/pnas.1716233114. Epub 2017 Nov 6.
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SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors.SP 和 IL-33 共同通过其受体的相互作用显著增强人肥大细胞介导的 TNF 的合成和分泌。
Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4002-E4009. doi: 10.1073/pnas.1524845114. Epub 2017 May 1.
3
Upregulated expression of substance P (SP) and NK1R in eczema and SP-induced mast cell accumulation.湿疹中P物质（SP）和神经激肽1受体（NK1R）的表达上调以及SP诱导的肥大细胞聚集。
Cell Biol Toxicol. 2017 Aug;33(4):389-405. doi: 10.1007/s10565-016-9379-0. Epub 2017 Feb 2.
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[Experimental study on substance P in the regulation of degranulation of cultured murine mast cells].[P物质对培养的小鼠肥大细胞脱颗粒调节作用的实验研究]
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Sep 7;51(9):675-680. doi: 10.3760/cma.j.issn.1673-0860.2016.09.008.
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Substance P selectively activates TNF-alpha gene expression in murine mast cells.P物质选择性激活小鼠肥大细胞中肿瘤坏死因子-α基因的表达。
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J Mol Med (Berl). 2005 May;83(5):386-96. doi: 10.1007/s00109-004-0627-z. Epub 2005 Mar 10.
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Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.小鼠皮肤NK1速激肽受体介导的P物质诱导的瘙痒相关反应
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本文引用的文献

1
IL-33/ST2 signaling boosts inflammation and pain.白细胞介素-33/ST2信号通路会加剧炎症和疼痛。
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10034-E10035. doi: 10.1073/pnas.1716120114. Epub 2017 Nov 6.
2
Role of Substance P Neuropeptide in Inflammation, Wound Healing, and Tissue Homeostasis.P物质神经肽在炎症、伤口愈合和组织稳态中的作用。
J Immunol. 2017 Sep 1;199(5):1543-1552. doi: 10.4049/jimmunol.1601751.
3
Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology.小鼠、脏小鼠与人类：利用小鼠理解人类免疫学
J Immunol. 2017 Jul 15;199(2):383-388. doi: 10.4049/jimmunol.1700453.
4
Tolerability and benefit of a tetramethoxyluteolin-containing skin lotion.含四甲氧基木犀草素的护肤乳液的耐受性和益处。
Int J Immunopathol Pharmacol. 2017 Jun;30(2):146-151. doi: 10.1177/0394632017707610. Epub 2017 May 8.
5
IL-33 in clinical practice: Size matters?白细胞介素-33在临床实践中的应用：量很重要吗？
J Allergy Clin Immunol. 2017 Aug;140(2):381-383. doi: 10.1016/j.jaci.2017.03.042. Epub 2017 May 4.
6
SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors.SP 和 IL-33 共同通过其受体的相互作用显著增强人肥大细胞介导的 TNF 的合成和分泌。
Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4002-E4009. doi: 10.1073/pnas.1524845114. Epub 2017 May 1.
7
Upregulated expression of substance P (SP) and NK1R in eczema and SP-induced mast cell accumulation.湿疹中P物质（SP）和神经激肽1受体（NK1R）的表达上调以及SP诱导的肥大细胞聚集。
Cell Biol Toxicol. 2017 Aug;33(4):389-405. doi: 10.1007/s10565-016-9379-0. Epub 2017 Feb 2.
8
Alternative splicing of interleukin-33 and type 2 inflammation in asthma.白细胞介素-33的可变剪接与哮喘中的2型炎症
Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8765-70. doi: 10.1073/pnas.1601914113. Epub 2016 Jul 18.
9
Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.活化的肥大细胞合成并释放可溶性ST2——一种白细胞介素-33的诱饵受体。
Eur J Immunol. 2015 Nov;45(11):3034-44. doi: 10.1002/eji.201545501. Epub 2015 Sep 9.
10
Genomic responses in mouse models poorly mimic human inflammatory diseases.小鼠模型中的基因组反应与人类炎症性疾病的反应相差很大。
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.

Reply to Fattori et al.: Action of SP and IL-33 on mast cells.

作者信息

Theoharides Theoharis C, Taracanova Alexandra, Tsilioni Irene, Conti Pio, Leeman Susan E

机构信息

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111;

Graduate Program in Pharmacology and Experimental Therapeutics, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111.

出版信息

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10036. doi: 10.1073/pnas.1716233114. Epub 2017 Nov 6.

DOI:10.1073/pnas.1716233114
PMID:29109296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5703332/
Abstract
摘要