College of Graduate Studies, Midwestern University, Glendale, Arizona, USA.
Center for Health Promotion and Disease Prevention, Edson College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona, USA.
Obesity (Silver Spring). 2021 Dec;29(12):2100-2107. doi: 10.1002/oby.23279. Epub 2021 Sep 28.
This study aimed to examine whether total, regional, and organ fat predicts bone marrow adipose tissue (BMAT) fat content and to explore whether BMAT fat content differs by sex among Latino youth.
Latino youth (n = 86; age 13.6 [1.4] years, 62% male) with obesity (BMI percentile = 98.5% [1.2%]) underwent a dual-energy x-ray absorptiometry scan to assess body composition and a magnetic resonance imaging scan to determine abdominal adiposity, liver fat, and vertebral BMAT fat content in the thoracic (average of T8-T12) and lumbar (average of L1-L5) spine.
Male youth exhibited significantly greater thoracic (male youth = 30.8% [1.4%] vs. female youth = 24.5% [2.1%], p = 0.027) and lumbar (male youth = 36.3% [1.5%] vs. female youth = 30.2% [2.2%], p = 0.038) BMAT fat content compared with female youth. Visceral adipose tissue was a significant predictor of thoracic (β = 0.434, t[86] = 3.016, p = 0.003) and lumbar (β = 0.389, t[86] = 2.677, p = 0.009) BMAT fat content, explaining 8.9% and 6.9% of the variance, respectively. Liver fat was a significant predictor of both thoracic (β = 0.487, t[86] = 4.334, p < 0.001) and lumbar (β = 0.436, t[86] = 3.793, p < 0.001) BMAT fat content, explaining 17.6% and 13.8% of the variance, respectively.
Male youth had significantly greater thoracic and lumbar BMAT fat content than female youth. Greater BMAT fat content is associated with greater liver fat and visceral adipose tissue among youth with obesity. Further investigation of the mechanistic underpinnings of BMAT may help to differentiate its metabolic and bone-related functions.
本研究旨在探讨全身、局部和器官脂肪是否能预测骨髓脂肪组织（BMAT）脂肪含量，并探究 BMAT 脂肪含量在肥胖的拉丁裔青少年中是否存在性别差异。
共纳入 86 名肥胖（BMI 百分位数 = 98.5%[1.2%]）的拉丁裔青少年（年龄 13.6[1.4]岁，62%为男性），他们接受了双能 X 射线吸收法扫描以评估身体成分，并接受了磁共振成像扫描以确定腹部脂肪、肝脏脂肪和胸腰椎（T8-T12 平均值）和腰椎（L1-L5 平均值）的 BMAT 脂肪含量。
与女性青少年相比，男性青少年的胸腰椎（男性青年 = 30.8%[1.4%] vs. 女性青年 = 24.5%[2.1%]，p = 0.027）和腰椎（男性青年 = 36.3%[1.5%] vs. 女性青年 = 30.2%[2.2%]，p = 0.038）的 BMAT 脂肪含量显著更高。内脏脂肪组织是胸腰椎（β=0.434，t[86]=3.016，p=0.003）和腰椎（β=0.389，t[86]=2.677，p=0.009）BMAT 脂肪含量的显著预测因子，分别解释了 8.9%和 6.9%的方差。肝脏脂肪是胸腰椎（β=0.487，t[86]=4.334，p<0.001）和腰椎（β=0.436，t[86]=3.793，p<0.001）BMAT 脂肪含量的显著预测因子，分别解释了 17.6%和 13.8%的方差。
男性青少年的胸腰椎 BMAT 脂肪含量明显高于女性青少年。肥胖青少年的 BMAT 脂肪含量与肝脏脂肪和内脏脂肪组织的含量增加有关。进一步探究 BMAT 的潜在机制，可能有助于区分其代谢和骨骼相关的功能。
