Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Kiel, Germany.
Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-University Bochum, Bochum, Germany.
Eur J Clin Nutr. 2019 Jan;73(1):62-71. doi: 10.1038/s41430-018-0150-x. Epub 2018 Apr 18.
BACKGROUND/OBJECTIVES: We investigated whether fat mass (FM) and total adipose tissue (TAT) can be used interchangeably and FM per TAT adds to metabolic risk assessment.
SUBJECTS/METHODS: Cross-sectional data were assessed in 377 adults (aged 18-60 years; 51.2% women). FM was measured by either 4-compartment (4C) model or quantitative magnetic resonance (QMR); total-, subcutaneous- and visceral adipose tissue (TAT, SAT, VAT), and liver fat by whole-body MRI; leptin, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and triglycerides; resting energy expenditure and respiratory quotient by indirect calorimetry were determined. Correlations and stepwise multivariate regression analyses were performed.
FM and FM were associated with TAT (r = 0.96, r = 0.99) with a mean FM per TAT of 0.85 and 1.01, respectively. Regardless of adiposity, there was a considerable inter-individual variance of FM/TAT-ratio (FM/TAT-ratio: 0.77-0.94; FM/TAT-ratio: 0.89-1.10). Both, FM and TAT were associated with metabolic risks. Further, FM/TAT-ratio was positively related to leptin but inversely with CRP. There was no association between FM/TAT-ratio and VAT/SAT or liver fat. FM/TAT-ratio added to the variance of leptin and CRP.
Independent of FM or TAT, FM/TAT-ratio adds to metabolic risk assessment. Therefore, the interchangeable use of FM and TAT to assess metabolic risks is questionable as both parameters may complement each other.
背景/目的：我们研究了脂肪量（FM）和总脂肪组织（TAT）是否可以互换使用，以及 FM 与 TAT 的比值是否可以增加代谢风险评估。
受试者/方法：本横断面研究纳入了 377 名成年人（年龄 18-60 岁；51.2%为女性）。FM 通过四室模型（4C）或定量磁共振（QMR）进行测量；全身 MRI 测量 TAT、皮下脂肪和内脏脂肪（TAT、SAT、VAT）和肝脏脂肪；通过间接测热法测量瘦素、胰岛素、稳态模型评估的胰岛素抵抗（HOMA-IR）、C 反应蛋白（CRP）和甘油三酯；通过间接测热法测量静息能量消耗和呼吸商。进行相关性和逐步多元回归分析。
FM 与 TAT 呈高度相关（r=0.96，r=0.99），FM 与 TAT 的比值分别为 0.85 和 1.01。无论肥胖程度如何，FM/TAT 比值的个体间差异都很大（FM/TAT 比值：0.77-0.94；FM/TAT 比值：0.89-1.10）。FM 和 TAT 均与代谢风险相关。此外，FM/TAT 比值与瘦素呈正相关，与 CRP 呈负相关。FM/TAT 比值与 VAT/SAT 或肝脏脂肪无相关性。FM/TAT 比值与瘦素和 CRP 的变异相关。
独立于 FM 或 TAT，FM/TAT 比值可增加代谢风险评估。因此，用 FM 和 TAT 来评估代谢风险的互换使用是值得质疑的，因为这两个参数可能相互补充。
