脂肪细胞-肌成纤维细胞转化可能是雄激素性脱发的病理生理步骤之一。
Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia.
机构信息
Scientific Department, Wellcomet GmbH, Karlsruhe, Germany.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Exp Dermatol. 2017 Jun;26(6):522-523. doi: 10.1111/exd.13379.
Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
在毛囊退化过程中，其周围和下方出现局部纤维组织结构是雄激素性脱发（AGA）的已知特征。我们假设这种纤维化可能与最近发现的真皮脂肪细胞向肌成纤维细胞转化（AMT）有关，其中涉及真皮脂肪细胞。这表明 AMT 至少部分依赖于雄激素，我们提出 AMT 可能在 AGA 中起作用。
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