脂肪细胞-肌成纤维细胞转化可能是雄激素性脱发的病理生理步骤之一。
Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia.
机构信息
Scientific Department, Wellcomet GmbH, Karlsruhe, Germany.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Exp Dermatol. 2017 Jun;26(6):522-523. doi: 10.1111/exd.13379.
PMID:28482134
Abstract
Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
摘要
在毛囊退化过程中，其周围和下方出现局部纤维组织结构是雄激素性脱发（AGA）的已知特征。我们假设这种纤维化可能与最近发现的真皮脂肪细胞向肌成纤维细胞转化（AMT）有关，其中涉及真皮脂肪细胞。这表明 AMT 至少部分依赖于雄激素，我们提出 AMT 可能在 AGA 中起作用。
相似文献
1
Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia.脂肪细胞-肌成纤维细胞转化可能是雄激素性脱发的病理生理步骤之一。
Exp Dermatol. 2017 Jun;26(6):522-523. doi: 10.1111/exd.13379.
2
DERMAL ADIPOSE TISSUE IN HAIR FOLLICLE CYCLING: POSSIBLE APPLICATIONS IN ALOPECIA?毛囊周期中的真皮脂肪组织：在脱发治疗中的潜在应用？
Georgian Med News. 2017 Apr(265):41-45.
3
The diagnosis of androgenetic alopecia in children: Considerations of pathophysiological plausibility.儿童雄激素性脱发的诊断：病理生理学合理性的考虑。
Australas J Dermatol. 2019 Nov;60(4):e279-e283. doi: 10.1111/ajd.13079. Epub 2019 Jun 6.
4
Conditions simulating androgenetic alopecia.模拟雄激素性脱发的病症。
J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1258-64. doi: 10.1111/jdv.12915. Epub 2015 Jan 8.
5
6
Androgenetic alopecia.雄激素性脱发。
G Ital Dermatol Venereol. 2014 Feb;149(1):15-24.
7
Androgenetic alopecia in males: a histopathological and ultrastructural study.男性雄激素性脱发：一项组织病理学和超微结构研究。
J Cosmet Dermatol. 2009 Jun;8(2):83-91. doi: 10.1111/j.1473-2165.2009.00439.x.
8
Androgens and hair growth.雄激素与毛发生长。
Dermatol Ther. 2008 Sep-Oct;21(5):314-28. doi: 10.1111/j.1529-8019.2008.00214.x.
9
A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors.雄激素性脱发的假设发病机制模型：阐明二氢睾酮悖论和限速恢复因素。
Med Hypotheses. 2018 Feb;111:73-81. doi: 10.1016/j.mehy.2017.12.027. Epub 2017 Dec 30.
10
Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia.雄激素受体介导的旁分泌信号诱导雄激素性脱发真皮乳头内血管的退化。
J Invest Dermatol. 2022 Aug;142(8):2088-2099.e9. doi: 10.1016/j.jid.2022.01.003. Epub 2022 Jan 14.
引用本文的文献
1
Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications.胆汁纤维化是肝胆疾病中一个重要但被忽视的病理特征：从分子机制到临床意义。
Med Rev (2021). 2024 Jul 1;4(4):326-365. doi: 10.1515/mr-2024-0029. eCollection 2024 Aug.
2
Fibrosis Is a Basement Membrane-Related Disease in the Cornea: Injury and Defective Regeneration of Basement Membranes May Underlie Fibrosis in Other Organs.纤维化是角膜相关的基底膜疾病：基底膜的损伤和再生缺陷可能是其他器官纤维化的基础。
Cells. 2022 Jan 17;11(2):309. doi: 10.3390/cells11020309.
3
Fibroblasts: Origins, definitions, and functions in health and disease.成纤维细胞：起源、定义及在健康和疾病中的功能。
Cell. 2021 Jul 22;184(15):3852-3872. doi: 10.1016/j.cell.2021.06.024.
4
Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs.脂肪祖细胞可生成致病肌成纤维细胞：脂肪细胞向间充质细胞的转变及其在多个器官纤维化中新兴作用。
Curr Rheumatol Rep. 2020 Sep 25;22(11):79. doi: 10.1007/s11926-020-00957-w.
5
Thermogenic adipocytes: lineage, function and therapeutic potential.产热脂肪细胞：谱系、功能与治疗潜能。
Biochem J. 2020 Jun 12;477(11):2071-2093. doi: 10.1042/BCJ20200298.
6
Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences.脂肪基质细胞的扩增和耗竭：机制与后果。
Cells. 2020 Apr 2;9(4):863. doi: 10.3390/cells9040863.
7
The Role of Immature and Mature Adipocytes in Hair Cycling.成纤维细胞和成熟脂肪细胞在毛发周期中的作用。
Trends Endocrinol Metab. 2019 Feb;30(2):93-105. doi: 10.1016/j.tem.2018.11.004. Epub 2018 Dec 14.
8
The many secret lives of adipocytes: implications for diabetes.脂肪细胞的多重秘密生活：对糖尿病的影响。
Diabetologia. 2019 Feb;62(2):223-232. doi: 10.1007/s00125-018-4777-x. Epub 2018 Nov 21.
9
Skin aging as a mechanical phenomenon: The main weak links.皮肤衰老作为一种机械现象：主要薄弱环节。
Nutr Healthy Aging. 2018 Jun 15;4(4):291-307. doi: 10.3233/NHA-170037.
10
Emerging nonmetabolic functions of skin fat.皮肤脂肪的新兴非代谢功能。
Nat Rev Endocrinol. 2018 Mar;14(3):163-173. doi: 10.1038/nrendo.2017.162. Epub 2018 Jan 12.
Zotero 插件