毛囊周期中的真皮脂肪组织：在脱发治疗中的潜在应用？

DERMAL ADIPOSE TISSUE IN HAIR FOLLICLE CYCLING: POSSIBLE APPLICATIONS IN ALOPECIA?

作者信息

Wollina U, Abdel Naser M, Kruglikov I

机构信息

Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany; Department of Dermatology and Venereology, Ain Shams University Hospital, Cairo, Egypt; Wellcomet GmbH, Karlsruhe, Germany.

出版信息

Georgian Med News. 2017 Apr(265):41-45.

PMID:28574382

Abstract

Cross-talk between the hair follicles (HFs) in different stages of their cycling and adjacent adipose tissue is a new important topic which is of both theoretical and practical interest. Objective - to analyze available data on possible interrelationship of dermal adipose tissue and hair follicle cycling. Experimental results obtained in rodents clearly demonstrate that HFs cycling is connected to adjacent dermal adipose tissue. Recently uncovered adipocyte-myofibroblast transition can be significantly involved in miniaturization of HFs and be an important pathophysiological step in androgenetic alopecia. Improvement of adipogenic environment of HFs can be important both in treatment of alopecia and in surgical hair restoration procedures.

摘要

处于不同周期阶段的毛囊（HFs）与相邻脂肪组织之间的相互作用是一个新的重要课题，具有理论和实际意义。目的——分析关于真皮脂肪组织与毛囊周期可能的相互关系的现有数据。在啮齿动物身上获得的实验结果清楚地表明，毛囊周期与相邻的真皮脂肪组织有关。最近发现的脂肪细胞-肌成纤维细胞转变可能在毛囊小型化中起重要作用，并且是雄激素性脱发的一个重要病理生理步骤。改善毛囊的成脂环境在脱发治疗和外科毛发修复手术中都可能很重要。