Liao Zi-Xian, Kempson Ivan M, Fa Yu-Chen, Liu Meng-Chia, Hsieh Li-Chen, Huang Kuo-Yen, Wang Li-Feng
Institute of Medical Science and Technology, National Sun Yat-sen University , Kaohsiung, 80424, Taiwan.
Future Industries Institute, University of South Australia , Mawson Lakes, South Australia 5095, Australia.
Bioconjug Chem. 2017 Jun 21;28(6):1702-1708. doi: 10.1021/acs.bioconjchem.7b00162. Epub 2017 May 15.
Chemotherapy represents a conventional treatment for many cancers at different stages and is either solely prescribed or concomitant to surgery, radiotherapy, or both. However, treatment is tempered in instances of acquired drug resistance in response to either chemotherapy or targeted therapy, leading to therapeutic failure. To overcome this challenge, many studies focus on how cancer cells manipulate their genomes and metabolism to prevent drug influx and facilitate the efflux of accumulated chemotherapy drugs. Herein, we demonstrate magnetic adeno-associated virus serotype 2 (ironized AAV2) has an ability to be magnetically guided and transduce the photosensitive KillerRed protein to enable photodynamic therapy irrespective of drug resistance.
化疗是许多不同阶段癌症的传统治疗方法，可单独使用，也可与手术、放疗或两者同时使用。然而，在对化疗或靶向治疗产生获得性耐药的情况下，治疗效果会受到影响，导致治疗失败。为了克服这一挑战，许多研究聚焦于癌细胞如何操纵其基因组和代谢，以阻止药物流入并促进积累的化疗药物流出。在此，我们证明磁性2型腺相关病毒（铁离子化AAV2）具有被磁引导并转导光敏KillerRed蛋白以实现光动力治疗的能力，而不受耐药性影响。
