College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.
Int J Mol Sci. 2021 Feb 9;22(4):1728. doi: 10.3390/ijms22041728.
Photodynamic therapy (PDT) is a promising therapy due to its efficiency and accuracy. The photosensitizer is delivered to the target lesion and locally activated. Viral nanoparticles (VNPs) have been explored as delivery vehicles for PDT in recent years because of their favorable properties, including simple manufacture and good safety profile. They have great potential as drug delivery carriers in medicine. Here, we review the development of PDT photosensitizers and discuss applications of VNP-mediated photodynamic therapies and the performance of VNPs in the treatment of tumor cells and antimicrobial therapy. Furthermore, future perspectives are discussed for further developing novel viral nanocarriers or improving existing viral vectors.
光动力疗法（PDT）因其高效性和准确性而成为一种很有前途的治疗方法。光敏剂被递送到靶病变部位并局部激活。近年来，病毒纳米颗粒（VNPs）作为 PDT 的递送载体得到了探索，因为它们具有良好的性质，包括简单的制造和良好的安全性。它们作为药物递送载体在医学上具有巨大的潜力。在这里，我们综述了 PDT 光敏剂的发展，并讨论了 VNP 介导的光动力疗法的应用以及 VNPs 在肿瘤细胞治疗和抗菌治疗中的性能。此外，还讨论了进一步开发新型病毒纳米载体或改进现有病毒载体的未来展望。
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