Brünler Ronny, Aibibu Dilbar, Wöltje Michael, Anthofer Anna-Maria, Cherif Chokri
Institute of Textile Machinery and High Performance Material Technology (ITM), Technische Universität Dresden, Hohe Str. 6, 01069 Dresden, Germany.
Institute of Textile Machinery and High Performance Material Technology (ITM), Technische Universität Dresden, Hohe Str. 6, 01069 Dresden, Germany.
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:810-817. doi: 10.1016/j.msec.2017.03.105. Epub 2017 Mar 16.
Additive manufacturing technologies are a promising technology towards patient-specific implants for applications in regenerative medicine. The Net-Shape-Nonwoven technology is used to manufacture structures from short fibers with interconnected pores and large functional surfaces that are predestined for cell adhesion and growth. The present study reports on a modeling approach with a particular focus on the specific structural properties. The overall porosities and mean pore-sizes of the digital models are simulated according to liquid-displacement porosity in a tool implemented in the modeling software. This allows adjusting the process parameters fiber length and fiber diameter to generate biomimetic structures with pore-sizes adapted to the requirements of the tissue that is to be replaced. Modeling the structural and porosity properties of scaffolds and implants leads to an efficient use of the processed biomaterials as the trial-and-error method is avoided.
增材制造技术是一种很有前景的技术，可用于制造再生医学中针对特定患者的植入物。净形非织造技术用于由短纤维制造具有相互连接的孔隙和大功能表面的结构，这些结构适合细胞粘附和生长。本研究报告了一种建模方法，特别关注特定的结构特性。根据建模软件中实现的工具中的液体置换孔隙率，模拟数字模型的总体孔隙率和平均孔径。这允许调整工艺参数纤维长度和纤维直径，以生成具有适合待替换组织要求的孔径的仿生结构。对支架和植入物的结构和孔隙率特性进行建模可有效利用加工后的生物材料，因为避免了试错法。
