Hu Mei-Hua, Lin Kuang-Lin, Wu Chang-Teng, Chen Shih-Yen, Huang Go-Shine
1 Department of General Pediatric, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
2 Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
J Child Neurol. 2017 Aug;32(9):810-814. doi: 10.1177/0883073817707302. Epub 2017 May 8.
Norovirus has become increasingly recognized as causing viral gastroenteritis in children. Few data are available on the characteristics of children admitted to pediatric emergency departments with norovirus gastroenteritis and accompanying seizures. Our aim in this study was to describe the clinical features of, and risk factors for, seizures accompanying norovirus gastroenteritis. We collected 6359 stool samples from patients with gastroenteritis, of whom 1444 (22.71%) had laboratory-confirmed norovirus gastroenteritis. Of all patients, 108 (7.48%) children exhibited norovirus gastroenteritis and seizures; 49 (45.4%) were febrile, and 59 (54.6%) afebrile. The mean patient age was 2.31 ± 2.12 years; most were <5 years of age (92.6%). The afebrile group had a significantly higher incidence of 2 or more seizures than the febrile subjects ( P = .004). Early recognition and prompt treatment of convulsions associated with norovirus gastroenteritis in children are important. Future studies might explore the long-term prognoses of these patients.
诺如病毒已越来越多地被认为是导致儿童病毒性肠胃炎的病因。关于因诺如病毒肠胃炎并伴有癫痫发作而入住儿科急诊科的儿童的特征，现有数据较少。本研究的目的是描述诺如病毒肠胃炎伴发癫痫发作的临床特征及危险因素。我们收集了6359份肠胃炎患者的粪便样本，其中1444例（22.71%）经实验室确诊为诺如病毒肠胃炎。在所有患者中，108名（7.48%）儿童出现诺如病毒肠胃炎并伴有癫痫发作；49名（45.4%）发热，59名（54.6%）不发热。患者的平均年龄为2.31±2.12岁；大多数年龄小于5岁（92.6%）。无热组癫痫发作2次或更多次的发生率显著高于发热组（P = 0.004）。对儿童诺如病毒肠胃炎相关惊厥的早期识别和及时治疗很重要。未来的研究可能会探索这些患者的长期预后情况。
