Keum Ha Rim, Lee Seon Jin, Kim Jeong Min, Kim Sang Won, Baek Hee Sun, Byun Jun Chul, Kim Yu Kyung, Kim Saeyoon, Lee Jae Min
Department of Medicine, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea.
Medical Research Center, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea.
Children (Basel). 2023 Mar 9;10(3):529. doi: 10.3390/children10030529.
Febrile convulsion (FC) is the most common seizure disease in children, which occurs with a fever. We investigated the Korean Health Insurance Review and Assessment Service data of patients aged between 6 months and 5 years at the time of FC diagnosis. Diseases that can cause seizures with fever, such as neoplasms, metabolic disorders, nervous system disorders, cerebrovascular diseases, perinatal problems, and congenital abnormalities, were excluded. Weekly virus-positive detection rate (PDR) data were obtained from the Korea Disease Control and Prevention Agency for adenovirus, parainfluenza virus, respiratory syncytial virus (HRSV), influenza virus, coronavirus (HCoV), rhinovirus (HRV), bocavirus, metapneumovirus (HMPV), rotavirus, norovirus, and astrovirus. Using the Granger test, we then analyzed the monthly PDR and investigated the association between FC incidence and monthly PDR. We additionally identified monthly and seasonal FC incidence trends using the autoregressive integrated moving average. Between 2015 and 2019, 64,291 patients were diagnosed with FC. Annually, the incidence was the highest in May and the lowest in October. Most patients were diagnosed during the spring (26.7%). The PDRs for HRSV, HCoV, HRV, HMPV, and norovirus were associated with FC incidence after 1 month.
热性惊厥（FC）是儿童最常见的惊厥性疾病，通常伴有发热。我们调查了韩国健康保险审查与评估服务机构中FC诊断时年龄在6个月至5岁之间患者的数据。排除了可能导致发热性惊厥的疾病，如肿瘤、代谢紊乱、神经系统疾病、脑血管疾病、围产期问题和先天性异常。每周病毒阳性检出率（PDR）数据来自韩国疾病控制与预防机构，涉及腺病毒、副流感病毒、呼吸道合胞病毒（HRSV）、流感病毒、冠状病毒（HCoV）、鼻病毒（HRV）、博卡病毒、偏肺病毒（HMPV）、轮状病毒、诺如病毒和星状病毒。然后，我们使用格兰杰检验分析每月的PDR，并研究FC发病率与每月PDR之间的关联。我们还使用自回归积分滑动平均法确定了每月和季节性的FC发病趋势。2015年至2019年期间，64291名患者被诊断为FC。每年，发病率在5月最高，10月最低。大多数患者在春季被诊断（26.7%）。HRSV、HCoV、HRV、HMPV和诺如病毒的PDR与1个月后的FC发病率相关。
