Bagyura Zsolt, Kiss Loretta, Hirschberg Kristóf, Berta Balázs, Széplaki Gábor, Lux Árpád, Szelid Zsolt, Soós Pál, Merkely Béla
Heart and Vascular Center, Semmelweis University, Városmajor Utca 68, Budapest 1122, Hungary.
Department of Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany.
Dis Markers. 2017;2017:9548612. doi: 10.1155/2017/9548612. Epub 2017 Mar 7.
. In-stent restenosis (ISR) is the gradual narrowing of the vessel lumen after coronary stent implantation due to the increase in vascular smooth muscle cell proliferation. Vascular endothelial growth factor (VEGF) protein plays an important role in this process. Our aim was to analyze the association of single nucleotide polymorphisms of the VEGF gene (rs2010963 and rs6999447) with the occurrence of ISR after coronary artery bare metal stent (BMS) implantation. . 205 patients with a history of BMS implantation and a repeated coronarography were prospectively enrolled. Patients were assigned to diffuse restenosis group ( = 105) and control group ( = 100) and VEGF genotypes were determined. . Diffuse ISR was significantly more frequently observed in patients with homozygous normal genotype of rs2010963 polymorphism, and this polymorphism was independently associated with diffuse ISR. . RS2010963 is associated with higher incidence of development of diffuse coronary ISR in patients treated with BMS implantation.
支架内再狭窄（ISR）是冠状动脉支架植入后，由于血管平滑肌细胞增殖增加导致血管腔逐渐狭窄的过程。血管内皮生长因子（VEGF）蛋白在这一过程中起重要作用。我们的目的是分析VEGF基因单核苷酸多态性（rs2010963和rs6999447）与冠状动脉裸金属支架（BMS）植入后ISR发生的相关性。前瞻性纳入205例有BMS植入史且接受重复冠状动脉造影的患者。将患者分为弥漫性再狭窄组（n = 105）和对照组（n = 100），并确定VEGF基因型。rs2010963多态性纯合正常基因型患者中弥漫性ISR的发生率显著更高，且该多态性与弥漫性ISR独立相关。rs2010963与接受BMS植入治疗的患者发生弥漫性冠状动脉ISR的较高发生率相关。
