Szelid Zsolt, Lux Árpád, Kolossváry Márton, Tóth Attila, Vágó Hajnalka, Lendvai Zsuzsanna, Kiss Loretta, Maurovich-Horvat Pál, Bagyura Zsolt, Merkely Béla
Semmelweis University Heart and Vascular Center, Budapest, Hungary.
Semmelweis University Heart and Vascular Center, Budapest, Hungary; MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
PLoS One. 2015 Oct 30;10(10):e0141680. doi: 10.1371/journal.pone.0141680. eCollection 2015.
Nitric oxide (NO), an important endogenous pulmonary vasodilator is synthetized by the endothelial NO synthase (NOS3). Reduced NO bioavailability and thus the Glu298Asp polymorphism of NOS3 may enhance right ventricular (RV) afterload and hypertrophic remodeling and influence athletic performance. To test this hypothesis world class level athletes (water polo players, kayakers, canoeists, rowers, swimmers, n = 126) with a VO2 maximum greater than 50ml/kg/min were compared with non-athletic volunteers (n = 155). Cardiopulmonary exercise tests and cardiac magnetic resonance imaging (cMRI) were performed to determine structural or functional changes. Genotype distribution of the NOS3 Glu298Asp polymorphism was not affected by gender or physical performance. Cardiac MRI showed increased stroke volume with eccentric hypertrophy in all athletes regardless of their genotype. However, the Asp allelic variant carriers had increased RV mass index (32±6g versus 27±6g, p<0.01) and larger RV stroke volume index (71±10ml versus 64±10ml, p<0.01) than athletes with a Glu/Glu genotype. Genotype was not significantly associated with athletic performance. In the non-athletic group no genotype related differences were detected. The association between the NOS3 Glu298Asp polymorphism and RV structure and dimension in elite athletes emphasizes the importance of NOS3 gene function and NO bioavailability in sport related cardiac adaptation.
一氧化氮（NO）是一种重要的内源性肺血管舒张剂，由内皮型一氧化氮合酶（NOS3）合成。一氧化氮生物利用度降低，以及NOS3的Glu298Asp多态性，可能会增加右心室（RV）后负荷和肥厚性重塑，并影响运动表现。为了验证这一假设，将最大摄氧量大于50ml/kg/min的世界级水平运动员（水球运动员、皮划艇运动员、划艇运动员、赛艇运动员、游泳运动员，n = 126）与非运动员志愿者（n = 155）进行了比较。进行了心肺运动测试和心脏磁共振成像（cMRI）以确定结构或功能变化。NOS3 Glu298Asp多态性的基因型分布不受性别或身体表现的影响。心脏磁共振成像显示，所有运动员无论其基因型如何均出现每搏输出量增加并伴有离心性肥厚。然而，与Glu/Glu基因型运动员相比，Asp等位基因变异携带者的右心室质量指数增加（32±6g对27±6g，p<0.01），右心室每搏输出量指数更大（71±10ml对64±10ml，p<0.01）。基因型与运动表现无显著相关性。在非运动员组中未检测到与基因型相关的差异。精英运动员中NOS3 Glu298Asp多态性与右心室结构和尺寸之间的关联强调了NOS3基因功能和一氧化氮生物利用度在运动相关心脏适应中的重要性。
