Minhas Abdul M, Usman Muhammad Shariq, Khan Muhammad S, Fatima Kaneez, Mangi Muhammad A, Illovsky Michael A
GME Internal Medicine, Orange Park Medical Center.
Medical Student, Dow Medical College Karachi, Pakistan.
Cureus. 2017 Apr 6;9(4):e1142. doi: 10.7759/cureus.1142.
Association between non-alcoholic fatty liver disease (NAFLD) and various cardiovascular diseases has been demonstrated previously. Recent clinical studies have shown that increased circulating levels of γ glutamyl transpeptidase and liver transaminase, markers which are elevated in NAFLD, increase the risk of new-onset atrial fibrillation. We conducted a systematic review and meta-analysis of the available evidence to establish the possible association of increased chances of atrial fibrillation in patients with NAFLD. We extensively searched the PubMed, EMBASE, Cochrane Library, ISI Web of Science and Scopus databases to identify all possible studies that investigated the possible association of NAFLD with atrial fibrillation. Random effect models were used to pool the data between NAFLD and non-NAFLD group. I testing was done to assess the heterogeneity of the included studies. Our primary outcome was atrial fibrillation. A total of three studies including 1044 patients in the NAFLD arm and 1016 in the placebo arm were included. On pooled analysis, it was observed that patients with NAFLD had 2.5 times significantly higher chance (OR = 2.47, CI = 1.30-4.66, p = 0.005) of developing new-onset atrial fibrillation. Our meta-analysis identifies the paucity of high-quality evidence regarding the association between NAFLD and atrial fibrillation. More studies are needed to confirm the link between NAFLD and atrial fibrillation.
非酒精性脂肪性肝病（NAFLD）与各种心血管疾病之间的关联此前已得到证实。最近的临床研究表明，γ-谷氨酰转肽酶和肝转氨酶的循环水平升高，这些在NAFLD中升高的标志物会增加新发心房颤动的风险。我们对现有证据进行了系统评价和荟萃分析，以确定NAFLD患者发生心房颤动几率增加的可能关联。我们广泛检索了PubMed、EMBASE、Cochrane图书馆、ISI科学网和Scopus数据库，以识别所有调查NAFLD与心房颤动可能关联的研究。采用随机效应模型汇总NAFLD组和非NAFLD组的数据。进行I检验以评估纳入研究的异质性。我们的主要结局是心房颤动。共纳入三项研究，NAFLD组有1044例患者，安慰剂组有1016例患者。汇总分析显示，NAFLD患者发生新发心房颤动的几率显著高出2.5倍（OR = 2.47，CI = 1.30 - 4.66，p = 0.005）。我们的荟萃分析发现，关于NAFLD与心房颤动之间关联的高质量证据不足。需要更多研究来证实NAFLD与心房颤动之间的联系。
