非酒精性脂肪性肝病与老年中国人心房颤动风险增加相关：一项横断面研究。
Nonalcoholic Fatty Liver Disease Is Associated with Increased Atrial Fibrillation Risk in an Elderly Chinese Population: A Cross-Sectional Study.
机构信息
Department of Gastroenterology, Ningbo First Hospital, No. 59 Liuting Street, Haishu District, Ningbo, Zhejiang Province, China.
Ningbo University, College of Medicine, No. 818 Fenghua Road, Jiangbei District, Ningbo, Zhejiang Province, China.
出版信息
Biomed Res Int. 2018 Jul 19;2018:5628749. doi: 10.1155/2018/5628749. eCollection 2018.
BACKGROUND
Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There are rare researches performed among elderly adults.
AIMS
We conducted this cross-sectional analysis of elderly adults (≥65 years) to investigate the association between atrial fibrillation and nonalcoholic fatty liver disease.
METHODS
We analyzed clinical data of the elderly adults (≥ 65 years) who had health examination in Zhenhai Lianhua Hospital, Ningbo, China, in 2014.
RESULTS
522 of the 1688 participants were diagnosed with nonalcoholic fatty liver disease, and 39 participants were diagnosed as having atrial fibrillation. Nonalcoholic fatty liver disease was associated with risk factors for AF in the elderly Chinese population (OR 1.95, 95% CI 1.03-3.69). Adjustments for age, gender, systolic blood pressure, fasting plasma glucose, -glutamyl transpeptidase, high-density lipoprotein, triglycerides, total cholesterol and albumin, nonalcoholic fatty liver disease, and prevalent atrial fibrillation remained statistically significant (OR 2.76, 95% CI 1.32-5.77).
CONCLUSIONS
Our results show that nonalcoholic fatty liver disease is associated with an increased risk of atrial fibrillation in an elderly Chinese population.
背景
房颤和非酒精性脂肪肝疾病是两种在全球范围内高发的病理状况，它们具有多种心血管疾病风险因素。目前针对老年人的相关研究较少。
目的
我们对老年人（≥65 岁）进行了这项横断面分析，旨在研究房颤与非酒精性脂肪肝之间的关系。
方法
我们分析了 2014 年在中国宁波镇海龙莲医院接受体检的老年人（≥65 岁）的临床数据。
结果
在 1688 名参与者中，有 522 名被诊断为非酒精性脂肪肝疾病，有 39 名被诊断为房颤。非酒精性脂肪肝疾病与老年中国人群房颤的危险因素相关（OR 1.95，95%CI 1.03-3.69）。调整年龄、性别、收缩压、空腹血糖、γ-谷氨酰转肽酶、高密度脂蛋白、甘油三酯、总胆固醇和白蛋白、非酒精性脂肪肝疾病和已患房颤后，该关联仍具有统计学意义（OR 2.76，95%CI 1.32-5.77）。
结论
我们的结果表明，非酒精性脂肪肝疾病与中国老年人群中房颤风险的增加相关。
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