• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

65K DNA结合蛋白在单纯疱疹病毒1型复制早期出现。

The 65 K DNA binding protein appears early in HSV-1 replication.

作者信息

Schenk P, Ludwig H

机构信息

Institut für Virologie der Freien Universität Berlin.

出版信息

Arch Virol. 1988;102(1-2):119-23. doi: 10.1007/BF01315568.

DOI:10.1007/BF01315568
PMID:2848474
Abstract

During the infection cycle of herpes simplex virus polypeptides appear as immediate early, early and late proteins. We classified the 65 K DNA binding protein as an early (beta-) protein by comparing its detectibility with that of two well defined proteins the ICP 4 (known as immediate early protein) and the ICP 8 (known as early protein).

摘要

在单纯疱疹病毒的感染周期中，多肽以立即早期、早期和晚期蛋白的形式出现。通过将65K DNA结合蛋白的可检测性与两种明确的蛋白（ICP 4，即立即早期蛋白；ICP 8，即早期蛋白）的可检测性进行比较，我们将其归类为早期（β）蛋白。

相似文献

1
The 65 K DNA binding protein appears early in HSV-1 replication.65K DNA结合蛋白在单纯疱疹病毒1型复制早期出现。
Arch Virol. 1988;102(1-2):119-23. doi: 10.1007/BF01315568.
2
The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins.单纯疱疹病毒（HSV）蛋白ICP34.5是一种病毒体成分，它与增殖细胞核抗原和HSV复制蛋白形成DNA结合复合物。
J Neurovirol. 2003 Aug;9(4):477-88. doi: 10.1080/13550280390218788.
3
Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.单纯疱疹病毒ICP8 DNA复制蛋白在刺激晚期基因表达中的潜在作用。
J Virol. 1991 May;65(5):2666-75. doi: 10.1128/JVI.65.5.2666-2675.1991.
4
Altered properties of the herpes simplex virus ICP8 DNA-binding protein in cells infected with ICP27 mutant viruses.感染 ICP27 突变病毒的细胞中单纯疱疹病毒 ICP8 DNA 结合蛋白的特性改变
Virology. 1993 Sep;196(1):1-14. doi: 10.1006/viro.1993.1449.
5
HSV infected RAJI-cells specify HSV specific immediate early and/or early DNA-binding proteins.单纯疱疹病毒（HSV）感染的拉吉细胞（RAJI-cells）可产生HSV特异性的即刻早期和/或早期DNA结合蛋白。
Arch Virol. 1986;87(1-2):107-18. doi: 10.1007/BF01310547.
6
ICP8 Filament Formation Is Essential for Replication Compartment Formation during Herpes Simplex Virus Infection.ICP8细丝形成对于单纯疱疹病毒感染期间复制区室的形成至关重要。
J Virol. 2015 Dec 16;90(5):2561-70. doi: 10.1128/JVI.02854-15.
7
Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells.p53、视网膜母细胞瘤蛋白和宿主复制蛋白在疱疹病毒感染细胞中病毒复制位点的定位。
Nature. 1991 Jan 31;349(6308):429-31. doi: 10.1038/349429a0.
8
Selective recruitment of nuclear factors to productively replicating herpes simplex virus genomes.核因子向高效复制的单纯疱疹病毒基因组的选择性募集。
PLoS Pathog. 2015 May 27;11(5):e1004939. doi: 10.1371/journal.ppat.1004939. eCollection 2015 May.
9
Characterization of DNA sequence-common and sequence-specific proteins binding to cis-acting sites for cleavage of the terminal a sequence of the herpes simplex virus 1 genome.
J Virol. 1989 Mar;63(3):1059-68. doi: 10.1128/JVI.63.3.1059-1068.1989.
10
Effect of macrophage activation on resistance of mouse peritoneal macrophages to infection with herpes simplex virus types 1 and 2.巨噬细胞激活对小鼠腹腔巨噬细胞抵抗1型和2型单纯疱疹病毒感染的影响。
J Gen Virol. 1988 Aug;69 ( Pt 8):1999-2010. doi: 10.1099/0022-1317-69-8-1999.

引用本文的文献

1
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.组蛋白伴侣 HIRA 促进宿主固有免疫防御反应的诱导，以应对 HSV-1 感染。
PLoS Pathog. 2019 Mar 22;15(3):e1007667. doi: 10.1371/journal.ppat.1007667. eCollection 2019 Mar.
2
Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity.组蛋白伴侣HIRA将组蛋白H3.3沉积到外来病毒DNA上，并有助于抗病毒固有免疫。
Nucleic Acids Res. 2017 Nov 16;45(20):11673-11683. doi: 10.1093/nar/gkx771.
3
MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.

本文引用的文献

1
Herpes simplex virus non-structural proteins. III. Function of the major DNA-binding protein.单纯疱疹病毒非结构蛋白。III. 主要DNA结合蛋白的功能。
J Gen Virol. 1983 May;64(Pt 5):983-95. doi: 10.1099/0022-1317-64-5-983.
2
Monoclonal antibodies to three non-glycosylated antigens of herpes simplex virus type 2.针对单纯疱疹病毒2型三种非糖基化抗原的单克隆抗体。
J Gen Virol. 1982 Dec;63(2):297-305. doi: 10.1099/0022-1317-63-2-297.
3
Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4.
MORC3是早幼粒细胞白血病核小体的一个组成部分，在限制单纯疱疹病毒1型和人巨细胞病毒方面发挥作用。
J Virol. 2016 Sep 12;90(19):8621-33. doi: 10.1128/JVI.00621-16. Print 2016 Oct 1.
4
Herpes simplex virus 1 ubiquitin ligase ICP0 interacts with PML isoform I and induces its SUMO-independent degradation.单纯疱疹病毒 1 泛素连接酶 ICP0 与 PML 异构体 I 相互作用，并诱导其 SUMO 非依赖性降解。
J Virol. 2012 Oct;86(20):11209-22. doi: 10.1128/JVI.01145-12. Epub 2012 Aug 8.
5
A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence.一种病毒泛素连接酶具有底物偏好性 SUMO 靶向泛素连接酶活性，可对抗固有抗病毒防御。
PLoS Pathog. 2011 Sep;7(9):e1002245. doi: 10.1371/journal.ppat.1002245. Epub 2011 Sep 15.
6
Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0.一种无法表达立即早期调节蛋白ICP0的1型单纯疱疹病毒突变体的表型。
J Virol. 2004 Feb;78(4):1763-74. doi: 10.1128/jvi.78.4.1763-1774.2004.
7
Human neuron-committed teratocarcinoma NT2 cell line has abnormal ND10 structures and is poorly infected by herpes simplex virus type 1.人神经定向性畸胎瘤NT2细胞系具有异常的ND10结构，且对1型单纯疱疹病毒的感染性较差。
J Virol. 2001 Apr;75(8):3819-31. doi: 10.1128/JVI.75.8.3819-3831.2001.
8
A viral activator of gene expression functions via the ubiquitin-proteasome pathway.一种基因表达的病毒激活剂通过泛素-蛋白酶体途径发挥作用。
EMBO J. 1998 Dec 15;17(24):7161-9. doi: 10.1093/emboj/17.24.7161.
9
The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoforms.单纯疱疹病毒感染期间ND10的破坏与几种PML亚型的Vmw110和蛋白酶体依赖性缺失相关。
J Virol. 1998 Aug;72(8):6581-91. doi: 10.1128/JVI.72.8.6581-6591.1998.
针对1型单纯疱疹病毒蛋白的单克隆抗体，包括即刻早期蛋白ICP 4。
Infect Immun. 1981 Dec;34(3):684-92. doi: 10.1128/iai.34.3.684-692.1981.
4
A herpes simplex virus type 1 function continuously required for early and late virus RNA synthesis.一种单纯疱疹病毒1型功能，早期和晚期病毒RNA合成持续需要该功能。
Nature. 1980 May 29;285(5763):329-30. doi: 10.1038/285329a0.
5
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.疱疹病毒大分子合成的调控。I. 三组病毒蛋白合成的级联调控。
J Virol. 1974 Jul;14(1):8-19. doi: 10.1128/JVI.14.1.8-19.1974.
6
Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells.对感染细胞社会行为影响不同的单纯疱疹病毒株的特性分析。
J Gen Virol. 1968 May;2(3):357-64. doi: 10.1099/0022-1317-2-3-357.
7
Macromolecular synthesis in cells infected with herpes simplex virus.感染单纯疱疹病毒的细胞中的大分子合成
Nature. 1965 Jun 26;206(991):1374-5. doi: 10.1038/2061374a0.
8
The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1.单纯疱疹病毒1型的65,000道尔顿DNA结合及病毒体反式诱导蛋白
J Virol. 1987 Aug;61(8):2428-37. doi: 10.1128/JVI.61.8.2428-2437.1987.
9
Structures of herpes simplex virus type 1 genes required for replication of virus DNA.单纯疱疹病毒1型病毒DNA复制所需基因的结构。
J Virol. 1988 Feb;62(2):444-53. doi: 10.1128/JVI.62.2.444-453.1988.
10
Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis.鉴定单纯疱疹病毒1型中依赖于起始点的DNA合成所需的基因。
J Virol. 1988 Feb;62(2):435-43. doi: 10.1128/JVI.62.2.435-443.1988.