POLYMAT University of the Basque Country UPV/EHU , Joxe Mari Korta Center, Avenida Tolosa 72, 20018 Donostia-San Sebastian, Spain.
Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC , 13541 Gardanne, France.
ACS Appl Mater Interfaces. 2017 May 31;9(21):18254-18262. doi: 10.1021/acsami.7b02296. Epub 2017 May 16.
Recent interest in bioelectronics has prompted the exploration of properties of conducting polymer films at the interface with biological milieus. Poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) from a commercially available source has been used as a model system for these studies. Different cross-linking schemes have been used to stabilize films of this material against delamination and redispersion, but the cost is a decrease in the electrical conductivity and/or additional heat treatment. Here we introduce divinylsulfone (DVS) as a new cross-linker for PEDOT:PSS. Thanks to the higher reactiveness of the vinyl groups of DVS, the cross-linking can be performed at room temperature. In addition, DVS does not reduce electronic conductivity of PEDOT:PSS but rather increases it by acting as a secondary dopant. Cell culture studies show that PEDOT:PSS:DVS films are cytocompatible and support neuroregeneration. As an example, we showed that this material improved the transconductance value and stability of an organic electrochemical transistor (OECT) device. These results open the way for the utilization of DVS as an effective cross-linker for PEDOT:PSS in bioelectronics applications.
最近，生物电子学引起了人们的兴趣，促使人们探索与生物环境相互作用的导电聚合物薄膜的特性。来自商业来源的掺杂有聚苯乙烯磺酸盐的聚（3,4-亚乙基二氧噻吩）（PEDOT：PSS）已被用作这些研究的模型体系。已经使用了不同的交联方案来稳定这种材料的薄膜，以防止分层和再分散，但代价是电导率降低和/或需要额外的热处理。在这里，我们引入了二乙烯砜（DVS）作为 PEDOT：PSS 的新交联剂。由于 DVS 的乙烯基基团的反应性更高，因此可以在室温下进行交联。此外，DVS 不会降低 PEDOT：PSS 的电子电导率，反而可以通过充当二次掺杂剂来增加其电导率。细胞培养研究表明，PEDOT：PSS：DVS 薄膜具有细胞相容性，并支持神经再生。例如，我们表明，这种材料提高了有机电化学晶体管（OECT）器件的跨导值和稳定性。这些结果为在生物电子学应用中使用 DVS 作为 PEDOT：PSS 的有效交联剂开辟了道路。
