Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA.
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA.
Dev Cell. 2017 May 8;41(3):221-223. doi: 10.1016/j.devcel.2017.04.015.
In this issue of Developmental Cell, Kyogoku and Kitajima (2017) investigate the effect of cytoplasmic volume on the fidelity of chromosome segregation during meiosis in mouse oocytes. The authors find that large cytoplasmic volume affects spindle pole morphology, chromosome alignment, and stringency of checkpoint signaling, resulting in error-prone chromosome segregation.
在本期《发育细胞》中，Kyogoku 和 Kitajima（2017）研究了细胞质体积对小鼠卵母细胞减数分裂过程中染色体分离保真度的影响。作者发现，大的细胞质体积会影响纺锤体极的形态、染色体的排列以及检验点信号的严格程度，从而导致染色体分离出错。
