呼出一氧化氮分数（FeNO）和肺功能测定作为病理工作者吸入化学制剂暴露的指标。
Fractional Exhaled Nitric Oxide (FeNO) and Spirometry as Indicators of Inhalation Exposure to Chemical Agents in Pathology Workers.
作者信息
Suzuki Ritsuko Arakawa, Irokawa Toshiya, Ogawa Hiromasa, Ohkouchi Shinya, Tabata Masao, Togashi Susumu, Nakamura Takeshi, Ohisa Noriko, Nikkuni Etsuhiro, Miura Emiri, Yoshida Kaoru, Inomata Hiroshi, Kurosawa Hajime
机构信息
Department of Occupational Health, Tohoku University Graduate School of Medicine, Sendai, Japan (Drs Suzuki, Irokawa, Ogawa, Ohkouchi, Tabata, Ohisa, Nikkuni, Miura, Yoshida, Kurosawa); Center for Environmental Conservation and Research Safety, Tohoku University, Miyagi Prefecture, Japan (Drs Irokawa, Ogawa, Ohkouchi, Tabata, Kurosawa); and Environment Conservation Center, Tohoku University, Miyagi Prefecture, Japan (Togashi, Nakamura, Dr Inomata).
出版信息
J Occup Environ Med. 2017 May;59(5):467-473. doi: 10.1097/JOM.0000000000000976.
OBJECTIVE
The objective of this study was to examine whether fractional exhaled nitric oxide (FeNO) and spirometry can be used as indices to evaluate adverse health effects of low-concentrated chemical inhalation exposure, mainly to formaldehyde.
METHODS
Thirty-three subjects (pathology technicians) and 30 controls (workers without handling any chemicals in the same hospitals) participated in this study. All participants underwent FeNO measurement and spirometry before and after 5 days of work.
RESULTS
FeNO significantly increased in the subjects with a history of asthma (P < 0.05), whereas forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) decreased in the subjects (P < 0.05). Furthermore, work duration and pre-work levels of FEV1 in the subjects had a significant association.
CONCLUSION
The results suggest that FeNO, FVC, and FEV1 represent effective health-effect indices of low-concentrated chemical inhalation exposure.
目的
本研究的目的是检验呼出一氧化氮分数（FeNO）和肺功能测定是否可作为评估低浓度化学物质吸入暴露（主要是甲醛）对健康的不良影响的指标。
方法
33名受试者（病理技术员）和30名对照者（同一医院中未接触任何化学物质的工作人员）参与了本研究。所有参与者在工作5天前后均进行了FeNO测量和肺功能测定。
结果
有哮喘病史的受试者中FeNO显著升高（P<0.05），而这些受试者的用力肺活量（FVC）和第1秒用力呼气量（FEV1）下降（P<0.05）。此外，受试者的工作时长与工作前FEV1水平存在显著关联。
结论
结果表明，FeNO、FVC和FEV1是低浓度化学物质吸入暴露的有效健康影响指标。
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