Bohn Lucimere, Ramoa Ana, Silva Gustavo, Silva Nuno, Abreu Sandra Marlene, Ribeiro Fernando, Boutouyrie Pierre, Laurent Stéphane, Oliveira José
Research Center in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
Department of Biochemistry, Porto, University of Porto Faculty of Medicina, Portugal.
Int J Sports Med. 2017 May;38(5):396-401. doi: 10.1055/s-0043-101676. Epub 2017 May 9.
This study aimed to investigate whether sedentary time (Sed) and physical activity (PA) are associated with arterial stiffness in individuals with and without metabolic syndrome (MetS). This cross-sectional study comprised 197 individuals (47±13 years; 58% female) from a primary health care centre. Arterial stiffness was assessed using carotid-femoral pulse wave velocity (cfPWV). Metabolic syndrome was determined as clustering of at least 3 out of 5 risk factors (central obesity, hypertension, impaired glucose, triglycerides and high-density lipoprotein cholesterol). Daily PA was objectively assessed and classified in Sed, light and moderate-to-vigorous PA. Physical activity was used as a continuous variable for multiple regression analysis. For mean comparisons of cfPWV between subjects with and without MetS, a binary split at the median of Sed and PA was used. Sedentary time was associated with cfPWV (β=0.11; p=0.01) explaining 1.3% of its variance; independently of age (β=0.49; p<0.001), systolic blood pressure (β=0.27; p<0.001) and fasting glucose (β=0.19; p<0.001). Participants with MetS and more Sed had higher cfPWV than those with MetS and less Sed (9.9±1.0 vs. 8.9±1.0 m/s; p<0.05). Sedentary time is associated with cfPWV independently of age and metabolic risk factors. A higher Sed in MetS individuals lead to a worse arterial stiffness profile.
本研究旨在调查久坐时间（Sed）和身体活动（PA）与患有和未患有代谢综合征（MetS）的个体的动脉僵硬度之间是否存在关联。这项横断面研究纳入了来自一家初级医疗保健中心的197名个体（47±13岁；58%为女性）。使用颈股脉搏波速度（cfPWV）评估动脉僵硬度。代谢综合征被定义为5项危险因素（中心性肥胖、高血压、血糖受损、甘油三酯和高密度脂蛋白胆固醇）中至少3项聚集。客观评估每日PA并将其分为久坐时间、轻度和中度至剧烈PA。身体活动作为连续变量用于多元回归分析。为了比较患有和未患有MetS的受试者之间cfPWV的均值，在Sed和PA的中位数处进行二元划分。久坐时间与cfPWV相关（β=0.11；p=0.01），解释了其1.3%的方差；独立于年龄（β=0.49；p<0.001）、收缩压（β=0.27；p<0.001）和空腹血糖（β=0.19；p<0.001）。患有MetS且久坐时间较长的参与者比患有MetS且久坐时间较短的参与者具有更高的cfPWV（9.9±1.0 vs. 8.9±1.0 m/s；p<0.05）。久坐时间与cfPWV相关，独立于年龄和代谢危险因素。MetS个体中较高的久坐时间导致更差的动脉僵硬度状况。
