Graduate Program in Physical Education, University of Pernambuco, Recife, PE, Brazil.
School of Physical Education and Sports, University of São Paulo, São Paulo, SP, Brazil.
Atherosclerosis. 2018 Feb;269:211-218. doi: 10.1016/j.atherosclerosis.2018.01.009. Epub 2018 Jan 17.
Increased arterial stiffness is linked to increased risk of cardiovascular disease and mortality. Studies have reported conflicting results regarding the relationship between arterial stiffness and time spent in sedentary behavior (SB) and physical activity (PA). The objective of this systematic review and meta-analysis was to assess the relationship between objectively measured light PA (LPA), moderate to vigorous PA (MVPA), and SB with the gold standard measurement of arterial stiffness, carotid-femoral pulse wave velocity (cfPWV).
PubMed, Scopus, and Web of Science were searched for relevant studies published until November 2016. Studies reporting the correlation of objectively measured PA and SB with cfPWV in human adults >18 years old were included in this analysis. Correlation coefficients (CCs) were converted to Z scores via Fisher's z values for the analysis of summary effects, using a random-effects model.
Twelve studies were included in the systematic review. The meta-analysis showed a negative correlation between cfPWV and LPA (CC -0.16; 95% CI: -0.29 to -0.03; p=0.02) and MVPA (CC -0.16; 95% CI: -0.26 to -0.06; p<0.01), and a positive relationship between cfPWV and SB (CC 0.23; 95% CI: 0.12 to 0.35; p<0.01).
Time spent in light and moderate physical activities is associated with lower arterial stiffness, while time spent in SB is related to higher arterial stiffness. It suggests that PA at any intensity is favorable for arterial stiffness, whereas SB leads to increased arterial stiffness. Considering that cfPWV has an independent prognostic value, these associations may have important clinical implications.
动脉僵硬度的增加与心血管疾病风险和死亡率的增加有关。研究报告称，动脉僵硬度与久坐行为（SB）和体力活动（PA）之间的关系存在矛盾的结果。本系统评价和荟萃分析的目的是评估客观测量的低强度 PA（LPA）、中等到剧烈 PA（MVPA）和 SB 与动脉僵硬度的金标准测量颈动脉-股动脉脉搏波速度（cfPWV）之间的关系。
在 2016 年 11 月之前，在 PubMed、Scopus 和 Web of Science 上搜索了相关研究。本分析纳入了报告客观测量的 PA 和 SB 与成人（>18 岁） cfPWV 相关性的研究。使用随机效应模型，通过 Fisher 的 z 值将相关系数（CC）转换为 Z 分数，以进行汇总效应分析。
共有 12 项研究纳入系统评价。荟萃分析显示，cfPWV 与 LPA（CC-0.16；95%CI：-0.29 至-0.03；p=0.02）和 MVPA（CC-0.16；95%CI：-0.26 至-0.06；p<0.01）呈负相关，与 SB（CC 0.23；95%CI：0.12 至 0.35；p<0.01）呈正相关。
轻中度体力活动所花费的时间与较低的动脉僵硬度相关，而 SB 所花费的时间与较高的动脉僵硬度相关。这表明任何强度的 PA 都有利于动脉僵硬度，而 SB 则导致动脉僵硬度增加。鉴于 cfPWV 具有独立的预后价值，这些关联可能具有重要的临床意义。
