BACKGROUND

Natural products including are considered an incomparable source of molecular diversity that has led to the medicines, especially for pain treatment. To investigate the antinociception of , we examined its activity in a rat model of cisplatin neuropathy.

MATERIALS AND METHODS

Male Sprague-Dawley rats received intraperitoneal (i.p.) cisplatin twice a week at a dose of 2 mg/kg (cumulative dose, 20 mg/kg) for 4 weeks. Before each injection, 2 ml of sterile saline solution was given subcutaneously to prevent renal damage via hyperhydration. The mice were treated with gabapetin as a positive control drug with a 100mg/kg intraperitoneal injection. extract of 200mg/kg was solved in saline and then treated by oral administration.

RESULTS

The mice treated with showed lower withdrawal duration in the pin-prick and plantar tests, and a higher withdrawal threshold in the paw-withdrawal threshold test as compared to control animals in a cisplatin-induced neuropathic model. In the case of cold-allodynia, treatment increased paw-withdrawal duration in a chemical test. showed a more outstanding effect than gabapentin in all used tests for preventing cisplatin-induced nerve injury for 4 weeks.

CONCLUSIONS

Our results suggest that extract showed an antinociceptive effect in the pin-prick test, plantar test, and paw-withdrawal threshold test using a cisplatin-induced neuropathic rat model.