Lee Keyong Ho, Rhee Ki-Hyeong
CKD Research Institute, Chong Kun Dang Pharm., Yongin, 449-797, Republic of Korea.
College of Industrial Sciences, Kongju National University, Yesan 340-702, Republic of Korea.
Afr J Tradit Complement Altern Med. 2016 Aug 12;13(5):139-144. doi: 10.21010/ajtcam.v13i5.18. eCollection 2016.
Natural products including are considered an incomparable source of molecular diversity that has led to the medicines, especially for pain treatment. To investigate the antinociception of , we examined its activity in a rat model of cisplatin neuropathy.
Male Sprague-Dawley rats received intraperitoneal (i.p.) cisplatin twice a week at a dose of 2 mg/kg (cumulative dose, 20 mg/kg) for 4 weeks. Before each injection, 2 ml of sterile saline solution was given subcutaneously to prevent renal damage via hyperhydration. The mice were treated with gabapetin as a positive control drug with a 100mg/kg intraperitoneal injection. extract of 200mg/kg was solved in saline and then treated by oral administration.
The mice treated with showed lower withdrawal duration in the pin-prick and plantar tests, and a higher withdrawal threshold in the paw-withdrawal threshold test as compared to control animals in a cisplatin-induced neuropathic model. In the case of cold-allodynia, treatment increased paw-withdrawal duration in a chemical test. showed a more outstanding effect than gabapentin in all used tests for preventing cisplatin-induced nerve injury for 4 weeks.
Our results suggest that extract showed an antinociceptive effect in the pin-prick test, plantar test, and paw-withdrawal threshold test using a cisplatin-induced neuropathic rat model.
包括[具体内容缺失]在内的天然产物被认为是分子多样性的无与伦比的来源，这已产生了多种药物，尤其是用于疼痛治疗的药物。为了研究[具体内容缺失]的抗伤害感受作用，我们在顺铂诱导的神经病变大鼠模型中检测了其活性。
雄性Sprague-Dawley大鼠每周两次腹腔注射（i.p.）顺铂，剂量为2mg/kg（累积剂量20mg/kg），持续4周。每次注射前，皮下注射2ml无菌盐溶液，以通过水化作用预防肾损伤。小鼠腹腔注射100mg/kg加巴喷丁作为阳性对照药物进行治疗。将200mg/kg的[具体内容缺失]提取物溶于盐水中，然后口服给药。
在顺铂诱导的神经病变模型中，与对照动物相比，接受[具体内容缺失]治疗的小鼠在针刺和足底试验中的撤药持续时间较短，在爪撤离阈值试验中的撤药阈值较高。在冷痛觉过敏的情况下，[具体内容缺失]治疗在化学试验中增加了爪撤离持续时间。在所有用于预防顺铂诱导的神经损伤4周的试验中，[具体内容缺失]显示出比加巴喷丁更显著的效果。
我们的结果表明，使用顺铂诱导的神经病变大鼠模型，[具体内容缺失]提取物在针刺试验、足底试验和爪撤离阈值试验中显示出抗伤害感受作用。
