Frade Marco Andrey Cipriani, Assis Raimunda Violante Campos de, Coutinho Netto Joaquim, Andrade Thiago Antônio Moretti de, Foss Norma Tiraboschi
Division of Dermatology, Department of Internal Medicine, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.
An Bras Dermatol. 2012 Jan-Feb;87(1):45-51. doi: 10.1590/s0365-05962012000100005.
The vegetal biomembrane has been used to treat cutaneous ulcers.
To assess the role of the vegetal biomembrane on the chronic venous ulcers treatment compared to treatment with collagenase cream.
Fourteen patients were selected to be treated with vegetal biomembrane and 7 with Fibrase(®) (CONTROL), followed clinically and photographically by the Wound Healing Index by ImageJ during 120 days and biopsied on the 1(st) and 30(th) days for histological examination.
The vegetal biomembrane was better in promoting healing of the ulcers, especially on the inflammatory phase, confirmed by abundant exudation and wound debridement than the CONTROL group, on the 30th day. There was a greater tendency to angiogenesis followed by re-epithelialization with highest wound healing index on the 90(th) and 120(th) days.
A combined analysis of clinical and histopathological findings suggests that the vegetal biomembrane acted as a factor inducing wound healing, especially on the inflammatory phase, confirmed by abundant exudation of the lesions promoting the transformation of the microenvironment of the chronic venous ulcers, and also stimulating angiogenesis and subsequent re-epithelialization.
植物生物膜已被用于治疗皮肤溃疡。
与胶原酶乳膏治疗相比，评估植物生物膜在慢性静脉溃疡治疗中的作用。
选择14例患者用植物生物膜治疗，7例用纤维酶（®）（对照组）治疗，在120天内通过ImageJ软件的伤口愈合指数进行临床和摄影随访，并在第1天和第30天进行活检以进行组织学检查。
在第30天时，植物生物膜在促进溃疡愈合方面表现更好，尤其是在炎症期，表现为大量渗出和伤口清创，这一点比对照组更明显。在第90天和第120天时，有更大的血管生成趋势，随后是再上皮化，伤口愈合指数最高。
临床和组织病理学结果的综合分析表明，植物生物膜作为一种诱导伤口愈合的因素，尤其是在炎症期，病变的大量渗出促进了慢性静脉溃疡微环境的转变，同时刺激了血管生成和随后的再上皮化，这一点得到了证实。
