在一名人类免疫缺陷病毒（HIV）感染者中鉴定HIV包膜型特异性辅助性T细胞。
Identification of human immunodeficiency virus (HIV) envelope type-specific T helper cells in an HIV-infected individual.
作者信息
Walker C M, Steimer K S, Rosenthal K L, Levy J A
机构信息
Cancer Research Institute, University of California, School of Medicine, San Francisco 94143.
出版信息
J Clin Invest. 1988 Dec;82(6):2172-5. doi: 10.1172/JCI113841.
Abstract
Two T helper cell clones recognizing the gp 120 envelope protein of HIV were generated from the peripheral blood of a healthy seropositive individual. These cells were type specific as they proliferated and produced IL 2 when stimulated by an epitope in the amino-terminal half of gp 120 of HIVSF2, but not by a similar region of HIVZr6, a Zairian HIV-1 isolate. These two viruses differ by 26% in the deduced amino sequence of the gp 120 protein. Moreover, the antigenic site(s) recognized by the cloned T cells are distinct from those recognized by envelope-specific antibodies. These observations have important implications for the development and use of anti-HIV vaccines.
摘要
从一名健康血清阳性个体的外周血中产生了两个识别HIV gp120包膜蛋白的T辅助细胞克隆。这些细胞具有型特异性，因为当受到HIVSF2的gp120氨基末端一半中的一个表位刺激时它们会增殖并产生白细胞介素2，但受到扎伊尔HIV-1分离株HIVZr6的类似区域刺激时则不会。这两种病毒在gp120蛋白的推导氨基酸序列上有26%的差异。此外，克隆的T细胞识别的抗原位点与包膜特异性抗体识别的抗原位点不同。这些观察结果对抗HIV疫苗的开发和使用具有重要意义。
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