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用表达艾滋病病毒包膜糖蛋白的重组痘苗病毒免疫的黑猩猩体内针对艾滋病病毒糖蛋白的增殖性和细胞毒性T细胞。

Proliferative and cytotoxic T cells to AIDS virus glycoproteins in chimpanzees immunized with a recombinant vaccinia virus expressing AIDS virus envelope glycoproteins.

作者信息

Zarling J M, Eichberg J W, Moran P A, McClure J, Sridhar P, Hu S L

出版信息

J Immunol. 1987 Aug 15;139(4):988-90.

PMID:3497202
Abstract

PBL from chimpanzees immunized with a recombinant vaccinia virus that expresses HIV envelope glycoproteins ("env"), were found to proliferate after stimulation with HIV or with "env". Furthermore, CTL clones lytic for autologous target cells expressing HIV envelope glycoproteins were generated after stimulation of the chimpanzees' PBL with "env", indicating that immunization of these primates with a recombinant vaccinia virus primes HIV-specific CTL and also that HIV envelope glycoproteins serve as target antigens for CTL.

摘要

用表达HIV包膜糖蛋白（“env”）的重组痘苗病毒免疫的黑猩猩的外周血淋巴细胞（PBL），在受到HIV或“env”刺激后被发现会增殖。此外，在用“env”刺激黑猩猩的PBL后，产生了对表达HIV包膜糖蛋白的自体靶细胞具有裂解作用的细胞毒性T淋巴细胞（CTL）克隆，这表明用重组痘苗病毒免疫这些灵长类动物可引发HIV特异性CTL，并且HIV包膜糖蛋白可作为CTL的靶抗原。

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