从旧金山艾滋病患者中分离淋巴细胞病变逆转录病毒。

Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

作者信息

Levy J A, Hoffman A D, Kramer S M, Landis J A, Shimabukuro J M, Oshiro L S

出版信息

Science. 1984 Aug 24;225(4664):840-2. doi: 10.1126/science.6206563.

DOI:10.1126/science.6206563

PMID:6206563

Abstract

Infectious retroviruses have been detected in 22 of 45 randomly selected patients with acquired immune deficiency syndrome (AIDS) and in other individuals from San Francisco. The AIDS-associated retroviruses (ARV) studied in detail had a type D morphology, Mg2+-dependent reverse transcriptase, and cytopathic effects on lymphocytes. The viruses can be propagated in an established adult human T cell line, HUT-78. They cross-react with antiserum to the lymphadenopathy-associated retrovirus isolated from AIDS patients in France. Antibodies to ARV were found in all 86 AIDS patients and in a high percentage of 88 other homosexual men in San Francisco. This observation indicates the widespread presence of these lymphocytopathic retroviruses and their close association with AIDS.

摘要

在随机挑选的45名获得性免疫缺陷综合征（艾滋病）患者中的22名以及来自旧金山的其他个体中检测到了传染性逆转录病毒。经过详细研究的与艾滋病相关的逆转录病毒（ARV）具有D型形态、Mg2+依赖性逆转录酶，并且对淋巴细胞有细胞病变效应。这些病毒可以在已建立的成人人类T细胞系HUT-78中繁殖。它们与从法国艾滋病患者中分离出的淋巴结病相关逆转录病毒的抗血清发生交叉反应。在所有86名艾滋病患者以及旧金山88名其他同性恋男性中的高比例人群中发现了抗ARV抗体。这一观察结果表明这些淋巴细胞病变逆转录病毒广泛存在，并且它们与艾滋病密切相关。