抗体介导的心肌细胞钙通透性增强。
Antibody-mediated enhancement of calcium permeability in cardiac myocytes.
作者信息
Schultheiss H P, Kühl U, Janda I, Melzner B, Ulrich G, Morad M
机构信息
Department of Internal Medicine, Klinikum Grosshadern, University of Munich, Federal Republic of Germany.
出版信息
J Exp Med. 1988 Dec 1;168(6):2105-19. doi: 10.1084/jem.168.6.2105.
Abstract
Our study shows that antibodies, specific to the ADP/ATP carrier of the inner mitochondrial membrane, crossreact with the cell surface of cardiac myocytes, where the calcium channel seems to be the antigenic determinant. The antibodies enhanced the calcium current and suppressed its inactivation. Affinity-purified antibodies (IgG) exhibit an acute cytotoxic effect, which required extracellular calcium and was prevented by calcium channel blockers. Our findings suggest that antibody-mediated cytotoxicity results secondary to calcium overload caused by enhanced cellular calcium permeability, requiring no complement-dependent process.
摘要
我们的研究表明，针对线粒体内膜ADP/ATP载体的特异性抗体与心肌细胞的细胞表面发生交叉反应，其中钙通道似乎是抗原决定簇。这些抗体增强了钙电流并抑制其失活。亲和纯化的抗体（IgG）表现出急性细胞毒性作用，这需要细胞外钙，并且可被钙通道阻滞剂阻止。我们的研究结果表明，抗体介导的细胞毒性是细胞钙通透性增强导致钙超载的继发结果，不需要补体依赖过程。
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