1 Personalized Medicine Asthma and Allergy Clinic, Humanitas Research Hospital, and.
2 Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Am J Respir Cell Mol Biol. 2017 Dec;57(6):642-650. doi: 10.1165/rcmb.2016-0231TR.
Asthma is a heterogeneous chronic inflammatory disorder in which different endotypes contribute to define clinical inflammatory phenotypes. MicroRNAs (miRNAs) are a group of minute, endogenous 22-25 nt RNA elements that join to particular mRNAs to reduce translation and increase messenger RNA degradation. miRNAs operate in post-transcriptional control and regulate physiological and pathological processes in several illnesses. The purpose of this work is to review and discuss the current knowledge about the function of miRNAs in asthma, focusing particularly on their biological properties, pathophysiologic actions, and possible use as markers and treatments for asthma.
哮喘是一种异质性的慢性炎症性疾病，不同的表型有助于确定临床炎症表型。微小 RNA（miRNA）是一组微小的、内源性的 22-25nt RNA 元件，与特定的 mRNAs 结合，减少翻译并增加信使 RNA 降解。miRNAs 在转录后调控中发挥作用，调节多种疾病的生理和病理过程。本研究旨在综述和讨论 miRNA 在哮喘中的作用的现有知识，重点关注其生物学特性、病理生理作用以及作为哮喘标志物和治疗手段的可能用途。
