Mi Shuangli, Zhang Jian, Zhang Wei, Huang R Stephanie
Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China.
Laboratory of Disease Genomics and Individualized Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China ; Graduate university of Chinese Academy of Sciences, Beijing, China.
Microrna. 2013;2(1):63-71. doi: 10.2174/2211536611302010007.
MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate, high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAs have begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions between circulating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On the other hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulating miRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progress in identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs in the care of inflammatory diseases.
微小RNA（miRNA）是一类具有基因调控功能的小型非编码RNA分子，已在多种疾病的发病机制中发挥关键作用。当前的技术进步使得能够对不同组织中的miRNA丰度进行准确、高通量的分析。最近，细胞外循环miRNA已开始被证明是用于疾病诊断的高度稳定的血液生物标志物。了解循环miRNA与临床表型之间的相互作用可以增进我们对复杂疾病和特征的认识。另一方面，鉴于利用血液生物标志物的优势（例如，样本采集方便），循环miRNA作为生物标志物可能会改善疾病的诊断和管理。特别是，我们综述了将循环miRNA鉴定为几种常见炎症性疾病（包括哮喘、炎症性肠病和类风湿性关节炎）生物标志物的最新进展。目前的研究表明，循环miRNA在炎症性疾病的治疗中具有广阔的前景。
