Won Jae Yon, Kim Mirinae, Park Young-Hoon
Department of Ophthalmology and Visual Science, St. Paul's Hospital Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Medicine (Baltimore). 2017 May;96(19):e6709. doi: 10.1097/MD.0000000000006709.
The aim of the study was to investigate the thickness and volume profiles of each retinal layer in postoperative patients with epiretinal membranes.Twenty-four patients who underwent pars plana vitrectomy with internal limiting membrane (ILM) peeling for epiretinal membrane were included. The best corrected visual acuity, thickness, and volume were recorded from the medical records through a retrospective review. Spectral domain optical coherence tomography was used to measure the average thickness and volume of each retinal layer before surgery and 6 months postoperatively.All 24 patients were monitored for 60 months after surgery. In all Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, the thickness and volume of the retinal nerve fiber layer and the inner retinal layer decreased significantly. In contrast, the thickness and volume of the ganglion cell layer, inner nuclear layer, inner plexiform layer, and outer plexiform layer only decreased in some ETDRS subfields. Finally, there was no significant change in the thickness or volume of the outer nuclear layer (ONL), retinal pigment epithelium (RPE), and photoreceptor layers in all ETDRS subfields.The thickness and volume of the inner retina layer decreased significantly after pars plana vitrectomy using ILM peeling. However, there was no significant change in the thickness and volume of the outer retinal layers (ONL, RPE, and photoreceptor) after surgery.
本研究的目的是调查视网膜前膜术后患者各视网膜层的厚度和体积分布情况。纳入了24例行玻璃体切割联合内界膜（ILM）剥除术治疗视网膜前膜的患者。通过回顾性查阅病历记录最佳矫正视力、厚度和体积。使用频域光学相干断层扫描测量术前及术后6个月各视网膜层的平均厚度和体积。所有24例患者术后均随访60个月。在所有糖尿病视网膜病变早期治疗研究（ETDRS）子区域中，视网膜神经纤维层和视网膜内层的厚度和体积均显著降低。相比之下，神经节细胞层、内核层、内丛状层和外丛状层的厚度和体积仅在部分ETDRS子区域降低。最后，在所有ETDRS子区域中外核层（ONL）、视网膜色素上皮（RPE）和光感受器层的厚度或体积均无显著变化。使用ILM剥除术的玻璃体切割术后视网膜内层的厚度和体积显著降低。然而，术后视网膜外层（ONL、RPE和光感受器）的厚度和体积无显著变化。
