Mancuso Alexandra M, Gandhi Mona A, Slish Judianne
1 St John Fisher College Wegmans School of Pharmacy, Rochester, NY, USA.
2 UR Medicine Highland Hospital, Rochester, NY, USA.
J Pharm Pract. 2018 Apr;31(2):195-201. doi: 10.1177/0897190017708073. Epub 2017 May 11.
Solithromycin is a macrolide antibiotic that has undergone review for the treatment of community-acquired bacterial pneumonia. Solithromycin is also being investigated and has shown promise for the treatment of gonorrhea. With increasing antibiotic resistance, the development of novel antibiotics to combat infections is essential. The unique ribosome-binding stability of solithromycin and mild side effect profile make this a promising new antibiotic. This article will provide an overview on the mechanism of action, clinical efficacy, and safety of this drug for the treatment of gonorrhea. Relevant data were identified through a comprehensive literature search using multiple databases using the keywords solithromycin, CEM-101, and gonorrhea.
索利霉素是一种大环内酯类抗生素，已接受用于治疗社区获得性细菌性肺炎的审评。索利霉素也正在接受研究，并且已显示出治疗淋病的前景。随着抗生素耐药性的增加，开发新型抗生素来对抗感染至关重要。索利霉素独特的核糖体结合稳定性和轻微的副作用特征使其成为一种有前景的新型抗生素。本文将概述该药物治疗淋病的作用机制、临床疗效和安全性。通过使用索利霉素、CEM-101和淋病等关键词，利用多个数据库进行全面的文献检索，确定了相关数据。
