Department of Pulmonary Medicine, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Antimicrob Agents Chemother. 2018 Jul 27;62(8). doi: 10.1128/AAC.00588-18. Print 2018 Aug.
Evidence is provided that solithromycin is a bactericidal against not only fast-growing chlamydial organisms but also those slowed by gamma interferon (IFN-γ) At sublethal concentrations, Sol impedes homotypic fusion of -containing vacuoles and reduces secretion of the type III secretion (T3S) effector IncA. Sol may therefore represent a potential new clinical treatment for infections. Selective perturbation of the T3S system suggests a novel mode of antibacterial action for Sol that warrants further investigation.
有证据表明，索利霉素不仅对快速生长的衣原体病原体具有杀菌作用，而且对伽马干扰素（IFN-γ）抑制的病原体也具有杀菌作用。在亚致死浓度下，索利霉素可阻碍含有包涵体的空泡的同源融合，并减少 III 型分泌系统（T3S）效应蛋白 IncA 的分泌。因此，索利霉素可能代表了治疗 感染的一种新的潜在临床治疗方法。对 T3S 系统的选择性干扰表明，索利霉素具有一种新的抗菌作用模式，值得进一步研究。
