Zhang Xiaolin, Huang Chen, Zhao Yi, Jin Xiangyu
a College of Textiles, Donghua University , Shanghai , China.
J Biomater Sci Polym Ed. 2017 Sep;28(13):1408-1425. doi: 10.1080/09205063.2017.1329914. Epub 2017 May 22.
The fibrous drug-loading capability, degradation profile, drug release behavior and mechanical performance were found to be controlled by regulating the amount of IPA and chitosan, which delayed the degradable time-scale and improved the drug loading capacity. Six types of alginate fibers were spun by combining two distinct core flows with deionized water-based, ethanol-based and isopropyl alcohol-based sheath fluid, respectively. The as prepared fibers were analyzed and compared by the characterization of SEM, mass loss, ICP, FTIR, XRD, UV, mechanics performance testing and antibacterial activity tests. The results showed that fibers in the isopropyl alcohol with low polarity sheath flow exhibited higher-ordered structure. Also, incorporation of chitosan for the core stream strengthened the degree of crosslinking among the molecular chain, and thus made the fiber entrapped more drug of ampicillin molecular. The fibers, possessing superior mechanical properties, preferable drug loading capability, more prolonged drug release behavior and outstanding antibiotic activity, may offer a promising candidate for biomaterials, such as fibrous drug carrier and antibacterial sutures.
研究发现，通过调节异丙醇（IPA）和壳聚糖的用量，可以控制纤维的载药能力、降解特性、药物释放行为和力学性能，这延长了可降解时间尺度并提高了载药能力。分别将两种不同的芯流与去离子水基、乙醇基和异丙醇基鞘液相结合，纺制出六种类型的海藻酸盐纤维。通过扫描电子显微镜（SEM）表征、质量损失、电感耦合等离子体质谱（ICP）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、紫外光谱（UV）、力学性能测试和抗菌活性测试，对所制备的纤维进行分析和比较。结果表明，具有低极性鞘液的异丙醇中的纤维呈现出更高有序结构。此外，在芯流中加入壳聚糖增强了分子链间的交联程度，从而使纤维包封了更多的氨苄青霉素分子药物。这些纤维具有优异的力学性能、良好的载药能力、更长的药物释放行为和出色的抗菌活性，可能为生物材料提供一个有前景的候选者，如纤维药物载体和抗菌缝线。
