Gowrishankar Gayatri, Hardy Jonathan, Wardak Mirwais, Namavari Mohammad, Reeves Robert E, Neofytou Evgenios, Srinivasan Ananth, Wu Joseph C, Contag Christopher H, Gambhir Sanjiv Sam
Department of Radiology, Stanford University School of Medicine, Stanford, California.
Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
J Nucl Med. 2017 Oct;58(10):1679-1684. doi: 10.2967/jnumed.117.191452. Epub 2017 May 10.
6″-F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like F-FDG has been used to image and localize most cancers. However, unlike F-FDG, 6″-F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. 6″-F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. 6″-F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial strains. 6″-F-fluoromaltotriose was also able to detect in a clinically relevant mouse model of wound infection. The utility of 6″-F-fluoromaltotriose to help monitor antibiotic therapies was also evaluated in rats. 6″-F-fluoromaltotriose is a promising new tracer that has significant diagnostic utility, with the potential to change the clinical management of patients with infectious diseases of bacterial origin.
6″-氟麦芽三糖是一种正电子发射断层扫描（PET）示踪剂，它有可能用于对大多数细菌感染进行成像和定位，这与18F-氟代脱氧葡萄糖（F-FDG）用于对大多数癌症进行成像和定位的方式非常相似。然而，与F-FDG不同的是，6″-氟麦芽三糖不会被炎症性病变摄取，并且通过靶向在革兰氏阳性和革兰氏阴性细菌菌株中表达的麦芽糖糊精转运蛋白，似乎对细菌感染具有特异性。6″-氟麦芽三糖以高放射化学纯度合成，并在培养物和活体小鼠中的几种临床相关细菌菌株中进行了评估。6″-氟麦芽三糖在革兰氏阳性和革兰氏阴性细菌菌株中均被摄取。6″-氟麦芽三糖还能够在伤口感染的临床相关小鼠模型中检测到。6″-氟麦芽三糖在帮助监测抗生素治疗方面的效用也在大鼠中进行了评估。6″-氟麦芽三糖是一种有前景的新型示踪剂，具有显著的诊断效用，有可能改变细菌源性传染病患者的临床管理。
