Chen Liang-Fu, Zhou Allen S, West Anne E
Department of Neurobiology, Duke University, Durham, North Carolina.
Department of Neurobiology, Duke University, Durham, North Carolina
J Neurophysiol. 2017 Aug 1;118(2):755-770. doi: 10.1152/jn.00067.2017. Epub 2017 May 10.
The wiring of synaptic connections in the developing mammalian brain is shaped by both intrinsic and extrinsic signals. One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. Recent studies have elucidated a number of molecular mechanisms that allow nuclear transcription factors and chromatin regulatory proteins to encode aspects of specificity in experience-dependent synapse development. Here we review the evidence for the transcriptional mechanisms that sculpt activity-dependent aspects of synaptic connectivity during postnatal development and discuss how disruption of these processes is associated with aberrant brain development in autism and intellectual disability.
在发育中的哺乳动物大脑中，突触连接的布线受到内在和外在信号的共同塑造。这些调节途径汇聚的一个点是通过感觉经验依赖的新基因转录调节。最近的研究阐明了许多分子机制，这些机制使核转录因子和染色质调节蛋白能够在经验依赖的突触发育中编码特异性的各个方面。在这里，我们回顾了在出生后发育过程中塑造突触连接的活动依赖方面的转录机制的证据，并讨论了这些过程的破坏如何与自闭症和智力残疾中的异常大脑发育相关。
