Department of Clinical Oncology, Yamagata University Faculty of Medicine, Yamagata, Japan.
Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Kanagawa, Japan.
J Hum Genet. 2017 Sep;62(9):839-846. doi: 10.1038/jhg.2017.50. Epub 2017 May 11.
Recent progress in genomic research has raised expectations for the development of personalized preventive medicine, although genomics-related literacy of patients will be essential. Thus, enhancing genomics-related literacy is crucial, particularly for individuals with low genomics-related literacy because they might otherwise miss the opportunity to receive personalized preventive care. This should be especially emphasized when a lack of genomics-related literacy is associated with elevated disease risk, because patients could therefore be deprived of the added benefits of preventive interventions; however, whether such an association exists is unclear. Association between genomics-related literacy, calculated as the genomics literacy score (GLS), and the prevalence of non-communicable diseases was assessed using propensity score matching on 4646 participants (males: 1891; 40.7%). Notably, the low-GLS group (score below median) presented a higher risk of hypertension (relative risk (RR) 1.09, 95% confidence interval (CI) 1.03-1.16) and obesity (RR 1.11, 95% CI 1.01-1.22) than the high-GLS group. Our results suggest that a low level of genomics-related literacy could represent a risk factor for hypertension and obesity. Evaluating genomics-related literacy could be used to identify a more appropriate population for health and educational interventions.
最近，基因组学研究的进展提高了人们对个性化预防医学发展的期望，尽管患者的基因组学相关素养至关重要。因此，提高基因组学相关素养至关重要，特别是对于基因组学相关素养较低的个体，因为他们否则可能会错过接受个性化预防护理的机会。当基因组学相关素养低与疾病风险增加相关时，尤其应该强调这一点，因为患者可能因此被剥夺预防干预的额外益处；然而，这种关联是否存在尚不清楚。使用倾向评分匹配，在 4646 名参与者（男性：1891；40.7%）中评估了与非传染性疾病患病率相关的基因组学相关素养（计算为基因组学素养评分（GLS））。值得注意的是，低 GLS 组（评分低于中位数）患高血压的风险较高（相对风险（RR）为 1.09，95%置信区间（CI）为 1.03-1.16）和肥胖症（RR 为 1.11，95% CI 为 1.01-1.22）高于高 GLS 组。我们的研究结果表明，低水平的基因组学相关素养可能是高血压和肥胖症的一个危险因素。评估基因组学相关素养可用于确定更适合健康和教育干预的人群。
