慢性自发性荨麻疹患者循环中白细胞介素17浓度与C反应蛋白之间的关系。
The relationship between circulating concentrations of interleukin 17 and C reactive protein in chronic spontaneous urticaria.
作者信息
Grzanka A, Damasiewicz-Bodzek A, Kasperska-Zajac A
机构信息
Department of Internal Diseases, Dermatology and Allergology, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
Department of Chemistry, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.
出版信息
Allergy Asthma Clin Immunol. 2017 May 10;13:25. doi: 10.1186/s13223-017-0197-6. eCollection 2017.
BACKGROUND
Up-regulation of interleukin 17 (IL-17) family cytokines and acute phase response have been observed in patients with chronic spontaneous urticaria (CSU). It has been demonstrated that IL-17 stimulates C-reactive protein (CRP) expression.
AIM
To determine relationship between circulating concentrations of IL-17 and CRP in CSU.
METHODS
Concentrations of IL-17 in plasma and CRP in serum were measured in patients with CSU of varying severity and in the healthy subjects.
RESULTS
IL-17 and CRP concentrations were significantly higher in CSU patients as compared to the healthy subjects. In addition, there were significant differences in IL-17 and CRP concentrations between CSU patients with mild, moderate-severe symptoms and the healthy subjects. CRP did not correlate significantly with IL-17.
CONCLUSIONS
Increased circulating IL-17 concentration may represent an independent index of systemic inflammatory response in CSU, which is not related to increased CRP concentration.
背景
在慢性自发性荨麻疹（CSU）患者中已观察到白细胞介素17（IL-17）家族细胞因子上调和急性期反应。已证实IL-17刺激C反应蛋白（CRP）表达。
目的
确定CSU患者中循环IL-17浓度与CRP之间的关系。
方法
测定不同严重程度的CSU患者血浆中IL-17浓度和血清中CRP浓度，并与健康受试者进行比较。
结果
与健康受试者相比，CSU患者的IL-17和CRP浓度显著更高。此外，轻度、中度至重度症状的CSU患者与健康受试者之间的IL-17和CRP浓度存在显著差异。CRP与IL-17无显著相关性。
结论
循环IL-17浓度升高可能是CSU全身炎症反应的一个独立指标，与CRP浓度升高无关。
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