1 Department of Internal Diseases, Dermatology and Allergology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, Poland.
2 European Center for Diagnosis and Treatment of Urticaria (GA2LEN UCARE Network), Zabrze, Poland.
Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418784431. doi: 10.1177/2058738418784431.
LIGHT (homologous to lymphotoxins, exhibiting inducible expression, and competing with herpes simplex virus (HSV) glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) has been involved in various autoimmune and inflammatory disorders. LIGHT induces the expression of interleukin-8 (IL-8), which is up-regulated in chronic spontaneous urticaria (CSU). To determine circulating soluble LIGHT concentration and its relationship with IL-8 concentration in patients with CSU. Concentrations of LIGHT, IL-8, and C-reactive protein (CRP) were determined in plasma or serum of CSU patients by an enzyme-linked immunosorbent assay. LIGHT plasma concentration was significantly higher in moderate-severe CSU patients as compared with the healthy subjects, but not with mild CSU patients. There were significant correlations between increased LIGHT and IL-8 concentrations, but not with increased CRP in CSU patients. Enhanced plasma concentrations of soluble LIGHT and its association with IL-8 concentration suggest the role of LIGHT in systemic inflammatory activation in CSU patients. We hypothesize that LIGHT-mediated immune-inflammatory response plays a role in severe phenotypes of the disease.
LIGHT（与淋巴毒素同源，表现为诱导表达，并与单纯疱疹病毒 (HSV) 糖蛋白 D 竞争疱疹病毒进入介质 (HVEM)，HVEM 是 T 淋巴细胞表达的受体）参与了各种自身免疫和炎症性疾病。LIGHT 诱导白细胞介素-8 (IL-8) 的表达，而慢性自发性荨麻疹 (CSU) 中 IL-8 的表达上调。为了确定 CSU 患者循环可溶性 LIGHT 浓度及其与 IL-8 浓度的关系。通过酶联免疫吸附试验在 CSU 患者的血浆或血清中测定 LIGHT、IL-8 和 C 反应蛋白 (CRP) 的浓度。与健康受试者相比，中重度 CSU 患者的 LIGHT 血浆浓度明显升高，但与轻度 CSU 患者无差异。CSU 患者中，增加的 LIGHT 与 IL-8 浓度之间存在显著相关性，但与 CRP 增加无关。CSU 患者中可溶性 LIGHT 浓度升高及其与 IL-8 浓度的相关性表明 LIGHT 在全身性炎症激活中的作用。我们假设 LIGHT 介导的免疫炎症反应在疾病的严重表型中起作用。
